摘要
目的探讨磷酸肌酸钠早期治疗新生儿窒息的临床疗效及其对患儿心肌损伤标志物的影响。方法选取成都新世纪妇女儿童医院2015年5月—2017年8月收治的足月新生儿窒息患儿90例,随机分为对照组和试验组,各45例。对照组患儿采用常规基础治疗,试验组患儿在对照组基础上采用磷酸肌酸钠早期干预。比较两组患儿治疗前及治疗后24 h、7 d心肌损伤标志物[肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)、羟丁酸脱氢酶(α-HBDH)]变化情况。结果治疗前及治疗后24 h,两组患儿CK、CK-MB、LDH、α-HBDH比较,差异无统计学意义(P>0.05);治疗后7 d,两组患儿CK、CK-MB、LDH、α-HBDH低于治疗前及治疗后24 h(P<0.05),试验组患儿CK、CK-MB、LDH、α-HBDH低于对照组(P<0.05)。结论采用磷酸肌酸钠早期治疗新生儿窒息的临床效果明显,可有效降低患儿心肌损伤标志物,促进疾病早日康复。
Objective To dicuss the clinical effect of early phosphocreatine sodium in treating neonatal asphyxia and the impact on myocardial injury markers. Methods A total of 90 cases of neonatal asphyxia children were selected from May2015 to August 2017 in Chengdu New Century Women and Children’s Hospital,which were randomly divided into control group and experimental group,45 cases in each group. The control group was received routine treatment,and the experimental group was given early phosphocreatine sodium treatment. The myocardial injury markers（ CK,CK-MB,LDH,α-HBDH） before treatment and after treatment of 24 h,7 d were compared between the two groups. Results Before treatment and after treatment of 24 h,no siginificant differences of CK,CK-MB,LDH or α-HBDH was found between the two groups（ P 〉 0. 05）; after treatment of 7 d,the CK,CK-MB,LDH,α-HBDH of two groups were lower than before treatment and after treatment of 24 h（ P 〈 0. 05）,the CK,CK-MB,LDH,α-HBDH of experimental group were lower than control group（ P 〈 0. 05）. Conclusion Early application of phosphocreatine sodium has a significant effect in treating neonatal asphyxia,it can reduce myocardial injury markers,promoting the disease recovery.
作者
罗彩丹
LUO Cai -dan(Department of Neonatology, Chengdu New Century Women and Children＇s Hospital, Chengdu 610000, China)
出处
《临床合理用药杂志》
2018年第9期11-12,共2页
Chinese Journal of Clinical Rational Drug Use
关键词
新生儿窒息
磷酸肌酸钠
心肌损伤标志物
治疗结果
Neonatal asphyxia
Phosphocreatine sodium
Myocardial injury markers
Treatment outcome
