摘要
目的观察中药隔物外敷联合特定电磁波(TDP)法治疗膝骨关节炎(KOA)的疗效及安全性,明确该疗法的临床作用特点与优势,为临床应用提供依据。方法选取KOA患者共60例。随机分为治疗组(30例)和对照组(30例)。两组均给予盐酸氨基葡萄糖胶囊作为基础治疗,治疗组中药外敷联合TDP治疗,对照组联合美洛昔康治疗,疗程均为2周。两组患者于治疗前、后分别应用膝骨关节炎症状分级量化表及国际上公认的五种评分表(VAS疼痛评分表、Lequesne指数评分表、WOMAC骨关节炎评分量表、Lysholm膝关节功能评分表、WHO生存质量量表)进行评分,并对该疗法的不良反应进行安全性评价。结果两组治疗后膝骨关节炎症状积分、VAS评分、Lequesne评分、WOMAC量表积分、Lysholm评分、生活质量评分均较治疗前有改善,差异有统计学意义(P<0.01)。治疗后治疗组膝骨关节炎症状积分、VAS评分、Lequesne评分、WOMAC积分改善情况优于对照组,差异有统计学差异(P<0.05,P<0.01);Lysholm评分及患者生活质量评分两组比较,差异无统计学意义(P>0.05)。提示中药隔物外敷联合TDP治疗组疗效优于西药对照组。两组不良反应比较差异无统计学意义(P>0.05)。结论中药隔物外敷联合TDP疗法能有效缓解KOA患者的疼痛症状,改善膝关节活动功能,提高患者的生活质量,是安全的治疗手段,具有较好的临床应用价值。
Objective To observe the therapeutic effects and safety of the combined treatment for knee osteoarthritis（ KOA） with isolated Chinese herb application and TDP and determine the clinical effect characteristics and advantages of this therapy so as to provide the evidences for clinical application. Methods A total of 60 KOA patients were randomized into a treatment group（ 30 cases） and a control group（ 30 cases）. The glucosamine hydrochloride capsules were used as the basic treatment in the two groups. Additionally,in the treatment group,the combined therapy of the isolated Chinese herb application and TDP was applied. In the control group,meloxicam was added. The duration of treatment was 2 weeks. Before and after treatment,the symptom scale of KOA and 5 publicly-recognized scales（ VAS,Lequesne indexes,WOMAC scale,Lysholm knee joint scale and WHO Qo L） were adopted in the two groups for evaluation. The safety assessment was conducted in terms of the adverse reactions of this therapy. Results After treatment,the scores of KOA symptoms,VAS,Lequesne,WOMAS,Lyscholm and Qo L were all improved as compared with those before treatment in the two groups,indicating the significant differences（ P〈0. 01）. After treatment,the improvements in the scores of KOA symptoms,VAS,Lequesne and WOMAS in the treatment group were better than the control group,indicating the significant differences（ P〈0. 05,P〈0. 01）. The differences were not significant in Lyscholm and Qo L scores（ P〉0. 05）. It was suggested that the therapeutic effects of the combined therapy of the isolated Chinese herb application and TDP were better than the control group with western medicine. The differences were not significant in the adverse reactions between the two groups（ P〈0. 05）. Conclusion The combined therapy of the isolated Chinese herb application and TDP effectively relievespain and improves the motor function of knee joint and the quality of life in the KOA patients. It is the safe approach and valuable in clinical application.
作者
邵勤
周红梅
吴斌
李延萍
SHAO Qin;ZHOU Hong - mei;WU Bin;LI Yan- ping(Department of Rheumatology, Chongqing Chinese Medicine Hospital, Chongqing 400021)
出处
《世界中西医结合杂志》
2018年第3期410-413,共4页
World Journal of Integrated Traditional and Western Medicine
基金
重庆市科委/重庆市社会民生科技创新专项项目(cstc2015shmszx120105)
关键词
膝骨关节炎
中药隔物外敷
特定电磁波
Knee Osteoarthritis
Isolated Chinese Herb Application
TDP
