摘要
目的了解检测妊娠期25羟基维生素D_3血药浓度,并分析其影响因素。方法选取进行产前保健的孕妇1 756例,采用免疫层析法检测血清25羟基维生素D_3水平,将其结果按照年龄、季节和孕期分组。结果 1 756例孕妇的25羟基维生素D_3水平均较低,平均水平为44.763±17.076nmol·L^(-1)。高龄组孕妇25(OH)VD_3平均水平(43.812±17.080nmol·L^(-1))低于低龄组(45.715±17.072nmol·L^(-1)),但2组间差异无统计学意义(P>0.05);不同季节孕妇的25羟基维生素D_3平均水平不同,秋季25羟基维生素D_3平均水平最高,与其他3个季节比较差异有统计学意义(P<0.01):春季(3~5月)45.632±22.828nmol·L^(-1),夏季(6~8月):44.443±15.986nmol·L^(-1),秋季(9~11月):51.264±9.499nmol·L^(-1),冬季(12~2月):44.806±17.453nmol·L^(-1);不同孕期25羟基维生素D_3平均水平不同,孕中期低于孕早期(P<0.01),孕早期:41.870±12.883nmol·L^(-1),孕中期:44.848±18.641nmol·L^(-1)。结论妊娠期血清25羟基维生素D_3水平处于缺乏状态,年龄、季节及孕周均可影响25羟基维生素D_3水平,高龄孕妇、夏冬季节以及孕中期更易出现缺乏的现象。因此,应注意各种高危因素,结合25羟基维生素D_3浓度,及时足量补充25羟基维生素D_3,预防并发症的发生。
Objective To investigate the serum concentration of 25 hydroxyl vitamin D3 in pregnancy and to analyze its influencing factors.Methods1 756 pregnant women were selected for prenatal care,and the serum 25 hydroxyl vitamin D3 was detected by immuno-chromatography,and the results were grouped by age,season and pregnancy.Results The level of 25 hydroxyl vitamin D3 was lower in 1 756 pregnant women,with an average of 44.763±17.076 nmol·L^-1.The average level of 25 hydroxyl vitamin D3 in the elderly group（43.812±17.080 nmol·L^-1）was lower than the low age group（45.715±17.072 nmol·L^-1）,but there was no significant difference between the 2 groups（P〈0.05）.For different season average level of 25 hydroxyl vitamin D3,25 hydroxyl vitamin D3 in autumn was the highest,higher than the other 3 seasons obviously（P〈0.01）：spring（3-5 month）45.632±22.828 nmol·L^-1,summer（6-8 months）：44.443±15.986 nmol·L^-1,autumn（9-11 month）：51.264±9.499 nmol·L^-1,winter（12-2 months）：44.806±17.453 nmol·L^-1;the average level of 25 hydroxyl vitamin D3 during pregnancy was different,lower than the early stage of pregnancy（P〈0.01）,and the early gestational age：41.870±12.883 nmol·L^-1,the middle gestational age：44.848±18.641 nmol·L^-1.Conclusion The serum 25 hydroxyl vitamin D3 levels in pregnancy were in a state of deficiency,with age,season and gestational week affecting 25 hydroxyl vitamin D3 levels,which are more likely to be lacking in elderly women,summer and winter seasons,and mid-pregnancy.Therefore,attention should be paid to all kinds of risk factors,combined with 25 hydroxyl vitamin D3 concentration,to replenish 25 hydroxyl vitamin D3 in time to prevent complications.
作者
张静
何欣欣
石祥奎
姜英凤
曹政
ZHANG Jing;HE Xinxin;SHI Xiangkui;JIANG Yingfeng;CAO Zheng(Xuzhou Maternity and Child Health Care Hospital,Xuzhou 221009,China)
出处
《西北药学杂志》
CAS
2018年第3期392-395,共4页
Northwest Pharmaceutical Journal
关键词
25羟基维生素D3
血药浓度
孕周
高危因素
25 hydroxy vitamin D3
blood drug concentration
gestational age
risk factors
