摘要
神经退行性疾病、精神疾病和脑损伤等多种神经系统疾病的发生与神经炎症密切相关。先天免疫受体是脑内免疫防御的第一道防线,在神经炎症和神经系统疾病的发生发展过程中起到至关重要的作用。本综述重点围绕参与神经免疫的先天免疫受体,从先天免疫受体类型、功能作用和分子机制等几方面,详细阐述先天免疫受体介导的神经炎症在神经系统疾病中的功能作用和分子机制。同时,简要概述目前治疗神经退行性疾病药物的研究进展,以及靶向神经炎症的药物开发和临床治疗的可行性。
Neuroinflammation is closely associated with the development of neurodegeneration diseases, mental disorders and brain injuries. Innate immunity receptors are the first defense line against infections and injuries, which play a critical role in the neuroinflammation and nervous system diseases. This review, focuses on the type classification, function, regulatory mechanism for the innate immunity receptors, and illustrates their roles and molecular mechanism in the development of neuroinflammation and nervous system diseases. In addition, we will review the current drugs for treating related nervous system diseases, and the possibility of developing new drugs that target neuroinflammation and using anti-inflammatory drugs clinically.
作者
董渊
李晓恒
侯琳
程金波
DONG Yuan;LI Xiao-heng;HOU Lin;CHENG Jin-bo(Medical College, Qingdao University, Qingdao 266071, China;Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100069, China;Institute of military Cognitive and Brain Sciences, Academy of Military Medical Sciences, Beijing 100850, China)
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
2017年第11期1075-1083,共9页
Chinese Journal of Pharmacology and Toxicology
基金
中国博士后科学基金(2017M622142)
国家自然科学基金(81400987)~~
关键词
先天免疫受体
神经炎症
神经退行性疾病
精神疾病
脑损伤
innate immunity receptors
neuroinflammation
neurodegeneration diseases
mental disorders
brain injuries
