摘要
活性氧类(reactive oxygen species,ROS)在体内产生与清除的失衡,往往是导致机体病变的重要因素。研究表明,多条信号通路参与调节机体内ROS的平衡,其中核因子E2相关因子2-抗氧化反应元件(nuclear factor erythroid 2 related factor 2-antioxidant responsive element,Nrf2-ARE)通路活化,能诱导抗氧化酶表达,从而清除过量的活性氧,发挥细胞保护作用。Nrf2-ARE通路是当前研究的热点通路之一,阐明该通路活化或失活的分子机制亦是目前研究的重点。微RNA(microRNAs,miRNAs)是真核生物中广泛存在的能调节基因表达的一类非编码、极短小RNA分子,目前已发现多种miRNAs可作用于Nrf2-ARE信号通路上的重要分子,调控其表达,进而参与调控信号通路的活化与失活,在维持机体氧化还原稳态中扮演重要角色。现就近年来参与调控Nrf2-ARE通路的miRNAs的研究进展做一综述,以期为进一步阐明该通路在维持机体氧化反应稳态中的作用提供帮助。
The imbalance between production and removal of reactive oxygen species （ROS） in the body is an important factor leading to in vivo pathological changes. Previous studies have shown that muhiple signaling pathways are involved in mediating the balance of ROS formation and degradation in the living organisms. Among these pathways, the nuclear factor erythroid 2 related factor 2-antioxidant responsive element （Nrf2- ARE） pathway plays a very important role in cytoprotective action through inducing the expression of antioxidant enzymes and scavenging excess ROS. Therefore, it is also the focus of current research to elucidate the molecular mechanisms of activation or inactivation of this pathway. MicroRNAs （miRNAs） are a group of very small and non-coding RNA molecule found widely in eukaryotes, which function in regulating gene expression. It has bee.n found that a variety of miRNAs can target key molecules in the Nrf2-ARE signaling path- way and regulate their expression, and therefore participate in the activation and inactivation of the signaling pathway. Current report shows that miRNAs play a significant role in the maintenance of redox homeostasis. Summarizing the recent research progress of miRNAs in regulating Nrf2-ARE pathway helps further clarify the role of this pathway in the process of the body＇ s redox reaction.
作者
郑皖
冯湘玲
杨飞
陈继华
ZHENG Wan;FENG Xiang-ling;YANG Fei;CHEN Ji-hua(Department of Nutrition Science and Food Hygiene, Xiangya School of Public Health, Central South University, Changsha 410078, Hunan, China;Hunan Co-lnnovation Center for Utilization of Botanical Functional Ingredients, Changsha 410128, Hunan, China)
出处
《生命科学研究》
CAS
CSCD
2018年第2期158-166,共9页
Life Science Research
基金
国家自然科学基金资助项目(81472972
81502787)
湖南省自然科学基金资助项目(2017JJ2401)
