摘要
目的探讨同型半胱氨酸(Hcy)及血清胱抑素C(Cys-c)水平与糖尿病周围神经病变(DPN)的相关性。方法选择确诊2型糖尿病患者203例,DPN(DPN+)组123例,非DPN(DPN-)组80例,测定Cys-c、Hcy等指标,并对两组的以上指标及基线数据进行统计学分析。结果 Hcy、Cys-c及病程在DPN+组较DPN-组显著升高(P<0.05),评估胰岛β细胞功能HOMA-islet(CP)在DPN-组较DPN+组明显升高(P<0.01);高水平Hcy组的DPN患病率明显升高;控制病程等影响因素后,Hcy水平与Cys-c水平呈显著正相关。结论高Hcy、Cys-c是DPN的重要危险因素,协同测定Hcy及Cys-c可能对DPN早期诊断有重要价值。
Objective To investigate the correlations among homocysteine（Hcy）level,serum cystatin C（Cys-c）and diabetic peripheral neuropathy（DPN）. Methods Two hundred and three diagnosed cases of type 2 diabetes were enrolled,including 123 DPN patients（DPN ＋）and 80 non-DPN（DPN-）patients. Levels of serumHcy,Cys-c,high-sensitivity C-reactive protein（hs-CRP）and fiber fibrinogen（Fg）were detected. The above indi-cators and the baseline data such as sex,age,duration,BMI,WHR,HOMA-IR（CP）,HOMA-islet（CP）werestatistically analyzed. Results Hcy,Cys-c,and the duration of the DPN＋ group were significantly higher thanthose in the DPN-group（P〈0.05,respectively）. HOMA-islet（CP）in the DPN-group was markedly higher thanthat in the DPN ＋ group（P〈0.01）. The prevalence of DPN in the high level of Hcy group was much higher thanthat in the low and the normal level of Hcy group. Hcy was still significantly correlated with the Cys-c after takingthe controlled procedure such as duration and fibrinogen. Conclusion High levels of Hcy and Cys-c are the criti-cal risk factors of DPN,collaborative determination of Hcy and Cys-c level might be of quitevaluable in early diag-nosis of DPN.
作者
金明月
李国姣
郭妍
刘艺璇
吴兵书
陈彦彦
王应昉
王涤非
JIN Mingyue;LI Guojiao;GUO Yan;LIU Yixuan;WU Bingshu;CHEN Yanyan;WANG Yingfang;WANG Difei(Department of Geriatrics, the First Affiliated Hospital of China Medical University, Shenyang 110001, China)
出处
《实用医学杂志》
CAS
北大核心
2018年第8期1227-1230,共4页
The Journal of Practical Medicine
基金
国家自然基金资助(编号:81400839)
辽宁省科技计划项目(编号:2015225024
2016007024)
