摘要
目的:采用Meta分析的方法评价中药口服汤剂联合顺铂胸腔灌注治疗肺癌合并恶性胸腔积液(MPE)的疗效及安全性。方法:搜索中国知网、维普、万方、Pub Med、The Cochrane数据库自建库至2017年8月关于中药口服汤剂联合顺铂胸腔灌注治疗肺癌恶性胸腔积液的临床研究文献,选择符合要求的随机对照研究(RCT)。以生存期、总有效率、生活质量和主要不良反应为评价指标,采用相对危险度(RR)为效应量,使用Review Manager 5.3及Stata12.0软件进行Meta分析。结果:最终纳入21篇RCT共1 134例肺癌合并MPE患者。Meta分析结果显示,联合中药口服汤剂与顺铂胸腔灌注可以延长肺癌合并MPE患者的生存期,提高治疗有效率(RR=1.51,95%CI[1.34-1.70],P<0.00001),改善生活质量(RR=1.84,95%CI[1.53-2.20],P<0.00001),减少不良反应。结论:中药口服汤剂联合顺铂胸腔灌注治疗肺癌合并MPE较单用顺铂胸腔灌注治疗效果更好,且不良反应更少。
Objective： To evaluate the efficacy and safety of Chinese materia medica oral decoction combined with intrapleural cisplatin in the treatment of lung cancer with malignant pleural effusion（MPE） by Meta-analysis. Methods： Clinical research papers about Chinese materia medica oral decoction combined with intrapleural cisplatin for the treatment of lung cancer with MPE before August 2017 were searched based on the CNKI, VIP, Wan Fang, Pub Med and The Cochrane databases. Randomized controlled trials（RCTs） that met the requirements were selected. The primary outcome measures included the overall survival（OS）, overall response rate（ORR）, quality of life and toxicity were analyzed by the Revman 5.3 and STATA 12.0 software packages. Results： A total of 21 papers and 1 134 patients were analyzed. Chinese materia medica oral decoction combined with intrapleural cisplatin could significantly prolong the survival time, improve the ORR（RR=1.51, 95%CI[1.34-1.70], P〈0.00001） and the quality of life（RR=1.84, 95%CI[1.53-2.20], P〈0.00001）, reduce the adverse reactions in lung cancer patients with MPE. Conclusion： The efficacy of Chinese materia medica oral decoction combined with intrapleural cisplatin is better than intrapleural cisplatin therapy in the treatment of lung cancer with MPE, and the adverse action is less.
作者
金志超
施展
花宝金
JIN Zhi-chao;SHI Zhan;HUA Bao-jin(Oncology Department, Guang＇anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China;Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2018年第5期2154-2158,共5页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家自然科学基金项目(No.81603610)
国家"十二五"科技支撑计划项目(No.2014BAI10B01)
中国中医科学院博士研究生创新人才培养基金项目(No.CX201706)~~
关键词
肺癌
恶性胸腔积液
META分析
中医药
Lung cancer
Malignant pleural effusion
Meta-analysis
Traditional Chinese medicine
