摘要
铁广泛存在于脑组织中,适宜浓度的铁为神经细胞呼吸链传递、神经递质生成和髓鞘化所必需。年龄的增长往往伴随着脑内铁沉积的增加,在老年痴呆症（Alzheimer’s disease,AD）患者和帕金森症（Parkinson’s disease,PD）患者的脑中铁含量异常升高,导致氧化应激和内质网胁迫。Rab蛋白参与了细胞内多种膜转运途径,是连接多种膜转运途径的关键分子。Rab8A蛋白是众多Rab蛋白中的一种,参与葡萄糖转运,视紫红质的运输等过程。本研究发现,神经细胞中铁过量时,导致Rab8a的表达减少,其表达变化具有时间和浓度效应,可能是AD和PD的致病机制之一。
Iron extensively exists in brain tissues, iron is needed for mitochondrial respiration and synthesis of myelin, neurotransmitters. Accumulation of iron in the brain increases with age. Excess iron in the brain is associated with diseases like Alzheimer’s, Parkinson’s disease, leading to the formation of reactive oxygen species and ER stress. Rabs are molecular switches controlling multiple steps in membrane traffic. Rab8 A is founded to be a regulator of glucose and rhodopsin transport recently. In the present study, We found Rab8 A is reduced in iron overloaded neural cells, indicating a mechanism of Alzheimer’s and Parkinson’s disease.
作者
蒙苗
林晓思
卢小娟
段训威
王翠芳
吴文林
Meng Miao;Lin Xiaosi;Lu Xiaojuan;Duan Xunwei;Wang Cuifang;Wu Wenlin(Key Laboratory of Fujian Province in Preparation and Functional development of Active Substrate from Marine Algae, Quanzhou Normal University, Quanzhou, 362000;Institute of Oceanology and Food Science, Quanzhou Normal University, Quanzhou, 362000;The Second Middle School ofNanjing, Zhangzhou, 363603)
出处
《基因组学与应用生物学》
CAS
CSCD
北大核心
2018年第4期1838-1841,共4页
Genomics and Applied Biology
基金
教育部大学生创新创业训练项目(20141039905)
泉州师范学院预研基金(2016YYKJ16)共同资助
