摘要
目的比较病情稳定的抑郁症和精神分裂症患者认知功能的差异。方法选取40例抑郁症患者,44例精神分裂症患者和41例正常对照。采用汉密尔顿抑郁量表(HAMD),阳性和阴性症状评估量表(PANSS)评估临床严重程度,重复性成套神经心理状态测验(RBANS)评估认知功能。结果抑郁症患者在注意力因子评分显著低于正常;精神分裂症即刻记忆、视觉广度、注意力和延时记忆的评分都显著低于正常对照,延时记忆的评分也低于抑郁症患者。在线条定位、词汇回忆评分也显著低于抑郁症患者。进一步做相关分析显示,抑郁症患者数字广度测验(评价注意力)与抑郁症的严重程度呈负相关性。精神分裂症患者注意力总分与PANSS总分、一般精神病理得分、阳性症状评分和阴性症状评分与呈负相关性,症状越重,注意力评分越差。另外RBANS总分与PANSS总分和阳性症状总分也呈负相关性。结论抑郁症和精神分裂症患者都存在认知功能的损害,并且与症状严重度呈相关性,其中精神分裂症患者损害更重。
Objective To compare the cognitive function of the patients with major depressive disorder（ MDD）and schizophrenia（ SCH） when the symptoms are stable. Methods 40 patients with MDD,44 patients with SCH and 41 healthy controls were measured with repeatable battery for the assessment of neuropsychological status（ RBANS）. The severity of the symptoms was measured by Hamilton depression scale（ HAMD） and Hamilton anxiety scale（ HAMA） for patients with MDD,and positive and negative syndrome scale（ PANSS） for SCH. Results The scores of attention of MDD were significantly lower than healthy controls,while the scores of immediate memory,visuospatial,attention and delayed memory of SCH were significantly lower than healthy controls,the delayed memory was even significantly lower than MDD. The scores of digital span of MDD were negatively correlated with the scores of HAMD. The scores of attention of SCH were negatively related with the total score,the positive,the negative and general psychopathology subscales of PANSS. The total scores of RBANS were negatively related with the total score and positive subscale of PANSS. Conclusion The cognitive functions of MDD and SCH are all impaired even the symptoms are relieved and are negatively related with the severity of the symptoms,which are even worse in SCH.
作者
宋煜青
谭云龙
双梅
董问天
Song Yuqing;Tan Yunlong;Shuang Mei(Peking University Sixth Hospital, Institute of Mental Health, Beijing 100191;Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing 100191;National Clinical Research Center for Mental Disorders,Peking Universpj Sixth Hospital, Beijing 100191;Psychiatry Research Center, Beijing Huilongguan Hospital, Peking University, Beijing 100096)
出处
《安徽医科大学学报》
CAS
北大核心
2018年第4期610-613,共4页
Acta Universitatis Medicinalis Anhui
基金
国家自然科学基金青年科学基金项目(编号:81101008)
