摘要
水痘-带状疱疹病毒(varicella-zoster virus,VZV)在人体感染的不同阶段可表现出不同的临床表现,初次感染时表现为水痘,而后病毒潜伏于神经节中,当某些因素使其再激活时,临床上则表现为带状疱疹。miRNA是存在于真核生物内具有调控基因功能的非编码RNA。水痘和带状疱疹虽然由同一种病毒引起,但在感染不同时期引起机体miRNA表达的变化并不一致,这些表达水平不同的miRNA可能是导致水痘与带状疱疹不同临床表现的原因之一。带状疱疹后遗神经痛是带状疱疹最易发生且最难控制的并发症,其发生也可能与机体相关miRNA的表达变化有关。本文将综述VZV在不同感染时期导致不同临床表现时机体miRNA的变化以研究miRNA与VZV感染的关系。
Varicella-zoster virus （VZV） has different clinical manifestations in different stages of human infection. The manifestation of initial infection is varicella, and then the virus lurks in the ganglion, which leads to herpes zoster after activation by some factors miRNA, a non-coding RNA that exists in eukaryotic organisms, plays a regulatory role in genes. Although varicella and herpes zoster are caused by the same virus, the changes in miRNA expression are different due to infection at different stages, which may contribute to different clinical manifestations of varicella and herpes zoster. Postherpetic neuralgia is the common complication of herpes zoster which is, howev- er, the most difficult to control. It may also be related to the changes in expression of relevant miRNA. The paper will review the changes in miRNA in VZV with different clinical manifestations due to infection at different stages, thereby studying the rela- tionship between miRNA and VZV infection.
作者
徐海峰
齐瑞群
高兴华
XU Haifeng;QI Ruiqun;GAO Xinghua(Department of Dermatology, the First Affiliated Hospital of China Medical University, Shenyang 110001, China)
出处
《中国皮肤性病学杂志》
CAS
CSCD
北大核心
2018年第5期575-579,共5页
The Chinese Journal of Dermatovenereology
