摘要
目的 探讨研究心活素治疗顽固性心绞痛急性心功能失代偿患者临床疗效.方法 以随机抽签的模式将2015年5月至2016年5月于本院收治的顽固性心绞痛急性心功能失代偿患者中抽出60例,将其以不同的入院时间自愿的形式平均分成观察组和对照组.其中,对照组患者选择以硝酸甘油为其治疗药物,观察组选择心活素为患者治疗药物,两组患者治疗总有效率、不良反应发生率、病症发作频次、持续时间、心肌缺血总负荷评分、住院时间及各项指标变化等情况比较.结果 观察组患者治疗总有效率90.00％,高于对照组66.67％;观察组患者不良反应发生率16.67％,低于对照组40.00％;观察组患者急性心绞痛发作频次、持续时间、住院时间等治疗情况均较对照组优;观察组患者LVEF、BNP、心肌缺血总负荷评分及尿量等指标结果均优于对照组,差异有统计学意义（P＜0.05）.结论 针对顽固性心绞痛急性心功能失代偿患者采取心活素进行治疗,不仅有效提高患者治疗效率和改善其心功能,还有利于缓解其病症发作频率和缩短患者心绞痛时间,且其不良反应少,住院时间短,安全性更高,具有较好的临床价值,表明此类治疗方法值得临床上大力推广.
Objective To explore the clinical efficacy of cardiotensin for patients with acute cardiac dysfunction and intractable angina pectoris. Methods In a random lottery pattern, 60 patients with intractable angina pectoris and acute cardiac dysfunction treated at our hospital from May, 2015 to May, 2016 were selected and divided into an observation group and a control group according to different hospitalization time and their voluntary admission. The control group were treated with nitroglycerin and the observation group with cardiotensin. The total effective rate, incidence of adverse reactions, seizure frequency, duration, myocardial ischemia total load grade, length of hospital stay, and indicator changes were compared between these two groups. Results The total effective rate was higher in the observation group than in the control group （90.00% vs. 66.67%）. The incidence of adverse reactions was lower in the observation group than in the control group （16.67% vs. 40.00%）. The acute angina pectoris attack frequency, duration, hospitalization time, and other treatment conditions were better in the observation group than in the control group. The LVEF, BNP, myocardial ischemia score, and urine volume were all better in the observation group than in the control group, with statistical differences （all P〈 0.05）.Conclusion Cardiotensin for patients with intractable angina pectoris and acute cardiac decompensation not only effectively enhances the treatment effcacy and improve the cardiac function, but also alleviates symptoms, shortens the time of angina pectoris attack frequency, and has few adverse reactions, short hospitalization time, high safety, and good clinical value, so it is worth being clinically generalized.
作者
张淑丽
Zhang Shuli(Department of Cardiology, Laizhou People＇s Hospital, Laizhou 261400, China)
出处
《国际医药卫生导报》
2018年第10期1534-1537,共4页
International Medicine and Health Guidance News
关键词
心活素
顽固性心绞痛急性心功能失代偿
临床疗效
Cardiotensin
Acute cardiac dysfunction and intractable angina pectoris
Clinical effcacy
