摘要
目的探讨益智温胆汤治疗老年轻度认知功能障碍的有效性和安全性。方法 70例老年轻度认知功能障碍患者按随机数字表法分为两组各35例,对照组给予多奈派齐治疗,观察组加服益智温胆汤,比较两组中医症状评分、MMSE、Ds R、ADL评分、相关临床指标与不良反应。结果治疗后观察组中医症状总分、IL-6水平低于对照组;MMSE总分与Ds R评分、Ach与HDL-C水平高于对照组(P<0.05);两组药物不良反应率差异无统计学意义(P>0.05)。结论益智温胆汤对老年轻度认知功能障碍的临床疗效显著,安全性较高,具有借鉴意义。
Objective To explore the efficacy and safety of Yizhi Wendan decoction in the treatment of mild cognitive impairment in the elderly.Methods Seventy older patients with mild cognitive impairment were enrolled in this study and randomly divided into control and observation groups,35 cases in each group.The control group was given Donnelly treatment. The observation group was treated with Yizhi Wendan decoction in addition to the treatment for the control group. The TCM symptom score,MMSE,Ds R,ADL score,relevant clinical indicators and adverse reactions were compared between the two groups.Results The total scores of TCM syndromes and IL-6 level were lower while MMSE total score,Ds R score and levels of Ach and HDL-C were significantly higher in the observation group than those in the control group（ P〈0. 05）. There was no significant difference in adverse drug reactions between the two groups（ P〉0. 05）.Conclusion Yizhi Wendan decoction has significant clinical efficacy and safety in elderly patients with mild cognitive impairment.It is of reference value.
作者
顾亮亮
GU Liang-liang(Department of Neurology, Nanyang Central Hospital and Nanyang Hospital,Zhengzhou University ,Zhengzhou 473000 ,Chin)
出处
《实用医院临床杂志》
2018年第3期55-58,共4页
Practical Journal of Clinical Medicine
关键词
益智温胆汤
认知功能障碍
有效性
安全性
Yizhi Wendan Decoction
Cognitive dysfunction
Effectiveness
Safety
