摘要
目的:优选复方甘草软胶囊内容物的处方及工艺。方法:采用单因素筛选方法和正交试验L_9(3~4)法,以内容物沉降体积比和再分散性为考察指标,确定复方甘草软胶囊处方及制备工艺。结果:以PEG400为分散介质,药材冻干粉粉末过120目筛,助悬剂选择蜂蜡,润湿剂选择大豆卵磷脂;药粉与聚乙二醇400用量比为1:1.25,蜂蜡用量为2%,大豆卵磷脂用量为0.4%时,制得的内容物混悬液最为稳定。结论:该方法制得的软胶囊内容物均匀、稳定、流动性好。
Objective： To optimize the prescription and preparation of compound licorice soft capsule content. Methods： Single factor screening method and orthogonal test L9（34） method were used to detemfine the prescription and preparation process of compound licorice soft capsules with the sediment volume ratio and re-dispersibility of the contents as indicators. Results： The PEG400 was used as the dispersion medium. The lyophilized powder was passed through a 120-mesh sieve. The beeswax was selected as the suspending agent, and the soy lecithin was selected as the wetting agent. The ratio of the powder to the PEG400 was 1：1.25. The amount of beeswax was 2%, the amount of soybean lecithin was 0.4%. The resuhing content suspension is the most stable. Conclusion： The soft capsule content of this method is well-distributed and stable with high fluidity.
作者
李亚新
杨庆利
陈虹
高颖
LI Ya-xin;YANG Qing-li;CHEN Hong;GAO Ying(Graduate School, Tianjin Medical University, Tianjin 300070, China;Armed Police Gansu Corps Jiuquan City Detachment, Jiuquan 735000, China;Department of Pharmacognosy and Pharmacy, Logistics University- of People＇ s Armed Police Force, Tianjin 300309, China;Department of Pharmacy, Affiliated Hospital of Logistics University of People＇ s Armed Police Force, Tianjin 300162, China)
出处
《天津医科大学学报》
2018年第3期259-262,共4页
Journal of Tianjin Medical University
基金
国家“十二五”科技重大专项基金资助项目(2012ZX09103201-029)
关键词
甘草
软胶囊
正交设计
工艺研究
Chinese herb Glycyrrhiza glabra
soft capsule
orthogonal design
preparation research
