摘要
目的观察多靶点治疗老年肾病综合征(NS)患者的临床疗效。方法将60例老年NS患者随机分为治疗组和对照组各30例。对照组采用常规治疗,治疗组采用多靶点治疗联合小柴胡汤治疗,对比2组临床疗效、生化指标及不良反应。结果治疗组总有效率为90.0%高于对照组的66.7%,差异有统计学意义(χ~2=6.204,P<0.05)。2组治疗前24 h尿蛋白、血肌酐、血清白蛋白、三酰甘油水平比较差异无统计学意义(P>0.05);接受治疗后,治疗组24 h尿蛋白、血肌酐、血清白蛋白、三酰甘油水平优于对照组,差异有统计学意义(P<0.05)。治疗组不良反应发生率为13.3%低于对照组的36.7%,差异有统计学意义(χ~2=6.306,P<0.05)。结论多靶点治疗老年NS的临床疗效显著,值得临床推广应用。
Objective To observe the clinical effect of multi-target treatment in treatment of elderly nephrotic syndrome. Methods 60 cases patietns with elderly nephrotic syndrome were randomly divided into treatment group and control group,each of 30 cases. Control group was treatment by conventional treatment. Treatment group was treatment by multi-target and small Chinese thorowax root soup. After treatment,compared the clinical effect,biochemical Indicators and adverse reactions of 2 groups. Results The total efficiency of treatment group（ 90. 0%） was higher than that of control group（ 66. 7%）,the difference was statistic significantly（ χ^2= 6. 204,P〈0. 05）. The level of 24 h urine protein,serum creatinine,serum albumin,triglyceride of 2 group before treatment was no statistic significantly（ P〉0. 05）. After treatment,the level of 24 h urine protein,serum creatinine,serum albumin,triglyceride of treatment group was better than that of control gorup,the difference was statistic significantly（ P〈0. 05）. The adverse rates of treatment group（ 13. 3%） was lower than that of control group（ 36. 7%）,the difference was statistic significantly（ χ^2= 6. 306,P〈0. 05）. Conclusion Multi-target treatment combined with small Chinese thorowax voot soup in treatment of elderly nephrotic syndrome has a good effect,worthy of clinical application.
作者
梁品传
LIANG Pinchuan.(Department of Geriatrics, The People＇s Hospital of Guigang City, Guangxi Zhuang Autonomous Region, Guigang 537100, Chin)
出处
《临床合理用药杂志》
2018年第10期26-27,30,共3页
Chinese Journal of Clinical Rational Drug Use
关键词
多靶点治疗
中西结合
老年人
肾病综合征
Multi-target therapy
Chinese and Western combination
Elderly
Nephrotic syndrome
