摘要
目的 探讨小青龙汤联合西药治疗老年慢性喘息型支气管炎发作期的临床疗效.方法 选择2016年5月至2017年8月老年慢性喘息型支气管炎发作期患者80例,随机分为观察组与对照组,每组各40例.两组患者均给予常规西药治疗,观察组在此基础上联合小青龙汤加减治疗,连续治疗2周后对两组治疗效果进行评价,比较两组临床疗效及症状体征消失时间,并于治疗前后检测两组患者的肺功能、淋巴细胞培养上清液中细胞因子水平.结果 观察组总有效率97.50％高于对照组80.00％（P〈0.05）.观察组喘息、咳嗽咳痰、肺部哮鸣音消失时间分别（5.96±1.27）d、（7.06±1.24）d、（6.87±1.18）d,与对照组（8.85±1.85）d、（10.97±2.04）d、（10.86±1.45）d比较均明显缩短（P〈0.05）.两组治疗后FEV1％、FEV1/FVC均较治疗前显著上升（P〈0.05）;观察组治疗后FEV1％、FEV1/FVC显著高于对照组（P〈0.05）.两组治疗后淋巴细胞培养上清液中IL-2、IFN-γ水平均有明显升高,IL-4、IL-10水平均明显降低（P〈0.05）;观察组治疗后淋巴细胞培养上清液中IL-2、IFN-γ水平明显高于对照组,IL-4、IL-10水平明显低于对照组（P〈0.05）.结论 小青龙汤加减联合西药治疗老年慢性喘息型支气管炎发作期疗效显著,患者临床症状可快速缓解,肺功能显著提高,其作用机制可能与小青龙汤具有调节Th1/Th2平衡有关,值得临床推广应用.
Objective To explore the clinical effect ofXiao Qinglong decoction combined with western medicine in the treatment of chronic asthmatic bronchitis in the elderly. Methods 80 elderly patients with chronic asthmatic bronchitis in our hospital from May 2016 to August 2017 were selected as the research subjects. They were randomly divided into two groups, 40 cases in each group. Both groups of patients were treated with conventional western medicine. The observation group was treated with Xiaoqinglong Decoction. After Wvo weeks of continuous treatment, the treatment effects of the two groups were evaluated. The clinical efficacy and disappearance of symptoms and signs were compared between the two groups.Before and after treatment, the lung function and lymphocyte culture supematant cytokine levels were measured in both groups. Results The total effective rate of the observation group was 97.50% （ 39/40 ） , which was significantly higher than that of the control group （ 32/40 ） （ P〈0.05 ） . The disappearance time of wheezing, cough, expectoration and wheezing in the observation group were （ 5.96±1.27 ） d, （ 7.06±1.24 ） D and （ 6.87±1.18 ） d, which were significantly shorter than those in the control group （ 8.85±1.85 ） d, （ 10.97±2.04 ） d, （ 10.86±10.86 ） d （ P〈0.05 ） . After treatment, FEVI% and FEV1/FVC increased significantly （ P〈0.05 ） in the two groups （ P〈0.05 ） . After treatment, FEVI% and FEV1/FVC in the observation group were significantly higher than those in the control group （ P〈0.05 ） . The two groups after treatment of lymphocyte culture supernatant IL-2, IFN- gamma average water increased significantly, IL-4 and IL-10 levels were significandy lower （P〈0.05） ; the observation group after treatment, IL-2 lymphocyte culture supematant IFN- levels were significandy higher than the control group after treatment, IL-4 and IL-10 levels were significantly lower than the control group after treatment （P〈0.05） . Conclusion Xiaoqinglong decoction combined with western medicine in the treatment of the onset period of chronic asthmatic bronchitis in the elderly has a significant curative effect. The patient＇s clinical symptoms can be rapidly relieved and the lung function is significantly improved. The mechanism of action may be related to Xiaoqinglong decoction has the function of regulating Thl/Th2 balance, and it is worthy of clinical application.
出处
《浙江临床医学》
2018年第5期885-887,共3页
Zhejiang Clinical Medical Journal
关键词
小青龙汤
老年慢性喘息型支气管炎
急性发作期
肺功能
Xiao Qinglong decoction Elderly chronic asthmatic bronchitis Acute attack stage Pulmonary function
