摘要
目的:利用三维治疗计划系统对宫颈癌术后不同射野数调强放射治疗(IMRT)与三维适形放射治疗(3DCRT)的计划作剂量学比较,评价其剂量分布特点,试图根据不同情况选择最佳的治疗方案。方法:选择20例宫颈癌术后患者,利用三维治疗计划系统对每个病例分别模拟三野、五野、七野IMRT计划与四野3DCRT计划。在剂量体积直方图上,比较靶区和正常组织器官照射剂量、靶区内剂量分布均匀性和适形指数。结果:无论三野、五野、七野IMRT的靶区剂量覆盖和适形指数皆优于四野3DCRT,均匀性比较无显著差异。较四野3DCRT,IMRT能减少膀胱、直肠、小肠等正常器官的照射剂量。结论:IMRT技术在保证肿瘤放射剂量的同时可减少并发症的发生,应该更广泛地应用于临床,同时对于经济条件受限的患者采用三野IMRT较四野3DCRT受益。
Objective To compare the dosimetry of different-field intensity-modulated radiotherapy（IMRT） with four-field three-dimensional conformal radiotherapy（3 DCRT） after radical surgery for cervical carcinoma for evaluating the dose distributions, and select the optimal treatment plan according to different situations. Methods Twenty patients receiving radical surgery for cervical carcinoma were selected, and different plans, namely three-, five-and seven-field IMRT plan and four-field 3 DCRT, were designed for each patients. Based on the dose-volume histogram（DVH）, the irradiation dose of target areas, normal tissues and organs, the conformal index and homogeneity index of dose distributions in target areas were compared. Results The conformal index and dose coverage of target areas in three-, five-and seven-field IMRT was superior to those in four-field 3 DCRT, while the differences in homogeneity index were trivial. The irradiation doses of bladder, rectum, small intestine in IMRT were statistically lower as comparison with four-field 3 DCRT. Conclusion IMRT should be more widely used in clinic for it can ensure the irradiation dose of tumor and reduce the incidence of complication. Moreover, compared with four-field 3 DCRT, three-field IMRT is more beneficial for patients with poor economic conditions
作者
唐世强
邱小平
陈文韬
贺夔
王志芳
何志鹏
TANG Shiqiang1,2, QIU Xiaoping1, CHEN Wentao1, HE Kui2, WANG Zhifang2, HE Zhipeng2 （1. School of Nuclear Science and Technology, University of South China, Hengyang 421001, China; 2. Radiation Therapy Center, Chenzhou NO. 1 People＇s Hospital, Chenzhou 423000, China
出处
《中国医学物理学杂志》
CSCD
2018年第2期183-186,共4页
Chinese Journal of Medical Physics
关键词
宫颈癌
不同射野数
调强放射治疗
三维适形放射治疗
剂量学
cervical carcinoma
different fields
intensity-modulated radiotherapy
three-dimensional conformal radiotherapy
dosimetry
