摘要
目的探讨先天性心脏病伴肺动脉高压患者血清B型尿钠肽(BNP)、血管内皮生长因子(VEGF)及转化生长因子-β_1(TGF-β_1)水平的表达及其临床意义。方法选择2014年1月至2017年6月深圳市人民医院收治的左向右分流型先天性心脏病患者86例作为研究组,按照肺动脉收缩压(PASP)分为A组(PASP≤30 mm Hg,n=20)、B组(30 mm Hg≤PASP<50 mm Hg,n=42)和C组(PASP≥50 mm Hg,n=24),另选取同期医院体检的健康人80例作为对照组。比较研究组和对照组、不同PASP分组患者的血清BNP、VEGF及TGF-β_1水平,并采用Pearson相关性分析分析其与PASP的相关性。结果研究组患者的血清BNP、VEGF及TGF-β_1水平分别为(236.76±75.43)pg/m L、(403.32±89.87)pg/m L、(837.53±102.25)pg/m L,均明显高于对照组的(88.36±26.73)pg/m L、(86.73±22.45)pg/m L、(128.81±32.13)pg/m L,差异均有统计学意义(P<0.05);患者血清BNP、VEGF及TGF-β_1水平随PASP升高而升高,不同PASP分组患者血清BNP、VEGF及TGF-β_1水平两两比较差异均有统计学意义(P<0.05);Pearson相关性分析结果显示,先天性心脏病伴肺动脉高压患者血清BNP、VEGF及TGF-β_1水平与PASP呈正相关(r=0.684、0.572、0.521,P<0.05),血清BNP、VEGF与TGF-β_1呈正相关(r=0.512、0.554,P<0.05)。结论左向右分流型先天性心脏病存在血清BNP、VEGF及TGF-β_1异常升高,三者与PASP呈正相关。
Objective To investigate the expression serum type B natriuretic peptide（BNP）, vascular endothelial growth factor（VEGF） and transforming growth factor-β1（TGF-β1） levels in patients with congenital heart disease complicated with pulmonary hypertension and its clinical significance. Methods A total of 86 patients with left to right shunt congenital heart disease, who were treated in Shenzhen People＇s Hospital from January 2014 to June 2017, were selected as the study group and according to the pulmonary artery systolic pressure（PASP） divided into the group A（PASP30 mmHg, n=20）, group B（30 mmHg≤PASP50 mmHg, n=42）, group C（PASP≥50 mmHg, n=24）. Another 80 healthy people in the same period were selected as the control group. The levels of serum BNP, VEGF and TGF-β1 between the study group and the control group and different PASP groups were compared, and the correlation between them and PASP was analyzed. Results The serum levels of BNP, VEGF and TGF-β1 in the study group were（236.76 ± 75.43） pg/mL,（403.32 ± 89.87） pg/mL,（837.53 ± 102.25） pg/mL, respectively, which were significantly higher than corresponding（88.36±26.73） pg/mL,（86.73±22.45） pg/mL,（128.81±32.13） pg/mL in the control group（P〈0.05）. With the increase of PASP, the serum levels of BNP, VEGF and TGF-β1 increased, and the levels of serum BNP, VEGF and TGF-β1 in patients with different PASP groups were statistically different（P〈0.05）. Pearson correlation analysis showed that the levels of serum BNP, VEGF and TGF-β1 were positively correlated with PASP in patients with congenital heart disease complicated with pulmonary hypertension（r=0.684, 0.572, 0.521, all P〈0.05）, and the serum BNP, VEGF were positively correlated with TGF-β1 in patients with congenital heart disease complicated with pulmonary hypertension（r=0.512,0.554, all P〈0.05）. Conclusion The serum levels of BNP, VEGF and TGF-β1 are increased in left to right shunt congenital heart disease, and the three of them are positively correlated with PASP.
作者
叶钜亨
谢颖
李军
童玲
张传寿
YE Ju-heng;XIE Ying;LI Jun;TONG Ling;ZHANG Chuan-shou(Department of Cardiology, Shenzhen People＇s Hospital, Shenzhen 518020, Guangdong, CHINA;Department of Cardiovascular Pediatrics, Shenzhen Children＇s Hospital, Shenzhen 518038, Guangdong, CHINA)
出处
《海南医学》
CAS
2018年第9期1203-1205,共3页
Hainan Medical Journal
基金
广东省深圳市2017年科技研发资金医疗卫生系统基础研究项目(编号:JCYJ20170303155415885)
关键词
先天性心脏病
B型尿钠肽
血管内皮生长因子
转化生长因子-Β1
Congenital heart disease
Type B natriuretic peptide （BNP）
Vascular endothelial growth factor（VEGF）
Transforming growth factor-β1 （TGF-β1）
