摘要
目的观察孟鲁司特钠联合雾化吸入布地奈德治疗呼吸道合胞病毒(RSV)毛细支气管炎的疗效,并探讨其对患儿血清炎症因子的影响。方法选取2016年2月至2017年5月期间深圳市宝安区妇幼保健院儿科收治的RSV毛细支气管炎患儿202例为研究对象,根据随机数表法分为观察组与对照组,每组101例,对照组予雾化吸入布地奈德治疗,观察组联合应用孟鲁司特钠口服,疗程7 d;比较两组患儿的临床指标及血清免疫球蛋白E(Ig E)、白细胞介素-8(IL-8)及肿瘤坏死因子-α(TNF-α)水平的变化。结果观察组患儿的喘息缓解、哮鸣音消失、咳嗽消失及住院时间分别为(3.44±1.42)d、(5.62±1.75)d、(6.56±2.01)d、(6.78±2.19)d,明显少于对照组的(4.58±1.57)d、(6.59±2.62)d、(7.43±2.62)d、(7.91±2.94)d,差异均有统计学意义(P<0.05);治疗后,观察组患儿的血清TNF-α、IL-8及Ig E水平分别为(59.45±21.53)pg/m L、(17.68±6.18)pg/m L、(167.24±69.75)IU/m L,明显低于对照组的(81.48±31.25)pg/m L、(25.82±8.35)pg/m L、(190.36±54.18)IU/m L,差异均有统计学意义(P<0.05)。结论孟鲁司特钠联合雾化吸入布地奈德治疗RSV毛细支气管炎可有效降低患儿血清炎症因子水平,促进临床症状的缓解。
Objective To observe the effect of montelukast sodium combined with aerosol inhalation of budesonide in the treatment of respiratory syncytial virus（RSV） induced capillary bronchitis, and to investigate its effect on serum inflammatory factors. Methods A total of 202 children with RSV induced capillary bronchitis in Department of Pediatrics in Baoan District Maternal and Child Health Care Hospital Affiliated to Jinan University from February2016 to May 2017 were selected as the research objects and divided into observation group and control group according to the random number table method, with 101 cases in each group. The control group received budesonide inhalation therapy, and the observation group received montelukast sodium combined with aerosol inhalation of budesonide, with 7 days as a treatment course. The clinical indexes, serum immunoglobulin E（IgE）, interleukin-8（IL-8）, and tumor necrosis factor-α（TNF-α） were compared between the two groups. Results The asthma remission, wheeze disappearance,cough disappearance, and hospitalization time in observation group were（3.44±1.42） d,（5.62±1.75） d,（6.56±2.01） d,（6.78±2.19） d, respectively, which were significantly less than（4.58±1.57） d,（6.59±2.62） d,（7.43±2.62） d,（7.91±2.94） d in control group. After treatment, the TNF-α, IL-8, and IgE in observation group was（59.45 ± 21.53） pg/mL,（17.68 ± 6.18） pg/mL,（167.24 ± 69.75） IU/mL, respectively, which were significantly lower than（81.48 ± 31.25） pg/mL,（25.82 ± 8.35） pg/mL,（190.36 ± 54.18） IU/mL in control group. Conclusion Montelukast sodium combined with aerosol inhalation of budesonide can effectively reduce the level of serum inflammatory factors and promote the remission of symptoms in children with RSV induced capillary bronchitis.
作者
陈瑜
肖劲花
黄冬蕾
金慧敏
柳希
CHEN Yu;XIAO Jin-hua;HUANG Dong-lei;JIN Hui-min;LIU Xi(Department of Pharmacy 1. Department of Pediatrics;Shenzhen Baoan District Maternal and Child Health Care Hospital Affiliated to Jinan University, Shenzhen 518101, Guangdong, CHINA)
出处
《海南医学》
CAS
2018年第9期1212-1214,共3页
Hainan Medical Journal
关键词
呼吸道合胞病毒
毛细支气管炎
孟鲁司特钠
布地奈德
炎症因子
Respiratory syncytial virus
Capillary bronchitis
Montclukast sodium
Budesonide
Inflammatory factors
