摘要
目的分析氧化应激产物丙二醛(MDA)与生育力和精子参数的相关性。方法检索Pub Med、Cochrane、中国知网、万方数据库、维普数据库等国内外医学文献数据库,查找MDA与精子质量相关的文献,检索时间从建库至2017年8月,根据纳入和排除标准严格筛选文献,提取数据指标,将相关系数r转换为fisher's Z值,采用Rev Man 5.3软件进行Meta分析。结果共检索出英文文献766篇,中文文献233篇,经过筛选后纳入16篇文献。分析结果表明不育患者精液的MDA水平明显高于正常对照组(SMD=0.80,95%CI=0.67~0.92,P<0.01);MDA与精子活动率呈负相关(r=-0.35,95%CI=-0.41^-0.31,P<0.01);MDA与精子密度也呈负相关(r=-0.37,95%CI=-0.45^-0.28,P<0.01)。结论不育患者精液中MDA水平明显高于正常生育男性,并与精子活动率及密度呈负相关,MDA可作为诊断和治疗不育的敏感指标。
Objective To evaluate the association between oxidative stress product malondialdehyde（MDA）and fertility or sperm parameters by meta-analysis. Methods Databases including Pub Med, Cochrane Library, CNKI,Wan Fang Database, VIP, and other databases were searched from their inception to August 2017 to collect literature on the association between MDA and sperm quality. The studies were screened according to the inclusion and exclusion criteria. After extracting data and converting the correlation coefficient r to Fisher ＇s Z value, meta-analysis was carried out by Rev Man5.3. Results A total of 16 studies were chosen from 766 English papers and 233 Chinese literatures after screening. The analysis showed that the level of MDA in semen of infertile patients was significantly higher than the control group（SMD=0.80, 95%CI =0.67-0.92, P〈0.01）; MDA was negatively correlated with sperm motility（r=-0.35, 95%CI =-0.41--0.31, P〈0.01）; MDA was also negatively correlated with sperm density（r=-0.37, 95%CI =-0.45--0.28. P〈0.01）. Conclusion Oxidative stress product MDA is significantly higher in infertile men than that in fertile men, and negatively correlated with sperm motility and density, which can be used as a sensitive index for diagnosis and treatment of infertility.
作者
夏雨果
陈秋
汤志梅
陈慧臻
高坪
曾文彤
赵娟
陈岚
XIA Yu-guo;CHEN Qiu;TANG Zhi-mei;CHEN Hui-zhen;GAO Ping;ZENG Wen-tong;ZHAO Juan;CHEN Lan(Department of Urology 1. Department of Endocrinology;School of Clinical Medicine Affiliated Hospital Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan, CHINA)
出处
《海南医学》
CAS
2018年第9期1316-1320,共5页
Hainan Medical Journal
基金
国家中医临床研究基地专项基金(编号:JDZX2015216)
成都中医药大学附属医院院基金(编号:2016-D-YY-27)
关键词
丙二醛
不育
精子
META分析
相关系数
Malondialdehyde （MDA）
Infertility
Sperm
Meta-analysis
Correlation coefficient
