摘要
目的探讨乳果糖口服溶液联合谷氨酸钾注射液治疗肝性脑病的临床疗效。方法选取2014年4月—2017年4月在天门市第一人民医院治疗的肝性脑病患者114例为研究对象,将所有患者随机分为对照组和治疗组,每组各57例。对照组静脉滴注谷氨酸钾注射液,60 mL加入到生理盐水500 mL中,1次/d。治疗组在对照组的基础上口服乳果糖口服溶液,30 mL/次,3次/d。两组患者均连续治疗7 d。观察两组的临床疗效,比较两组的生化学指标和Child-Pugh评分。结果治疗后,对照组和治疗组的总有效率分别为75.44%、92.98%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组血氨、总胆红素(TBil)、丙氨酸氨基转移酶(ALT)和天门冬氨酸氨基转氨酶(AST)水平均显著下降,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗组这些生化学指标明显低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组Child-Pugh评分均显著下降,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗组Child-Pugh评分明显低于对照组,两组比较差异具有统计学意义(P<0.05)。结论乳果糖口服溶液联合谷氨酸钾注射液治疗肝性脑病具有较好的临床疗效,能改善精神状况,降低血氨水平,改善肝脏功能,安全性较好,具有一定的临床推广应用价值。
Objective To investigate the clinical efficacy of Lactulose Oral Solution combined with Potassium Glutamate Injection in treatment of hepatic encephalopathy. Methods Patients（114 cases） with hepatic encephalopathy in the First People＇s Hospital of Tianmen from April 2014 to April 2017 were randomly divided into control and treatment groups, and each group had 57 cases. Patients in the control group were iv administered with Potassium Glutamate Injection, 60 mL added into normal saline 500 mL, once daily. Patients in the treatment group were po administered with Lactulose Oral Solution on the basis of the control group, 30 mL/time, three times daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacies were evaluated, and biochemical indexes and Child-Pugh scores in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 75.44% and 92.98%, respectively, and there was difference between two groups（P＜0.05）. After treatment, blood ammonia, TBil, ALT, and AST levels in two groups were significantly decreased, and the difference was statistically significant in the same group（P＜0.05）. And biochemical indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups（P＜0.05）. After treatment, Child-Pugh scores in two groups were significantly decreased, and the difference was statistically significant in the same group（P＜0.05）. And the Child-Pugh score in the treatment group was significantly lower than those in the control group, with significant difference between two groups（P＜0.05）. Conclusion Lactulose Oral Solution combined with Potassium Glutamate Injection has clinical curative effect in treatment of hepatic encephalopathy, can improve the mental state, reduce blood ammonia levels, and improve liver function, with good safety, which has a certain clinical application value.
作者
殷刚
罗良弢
谭海洋
严想元
YIN Gang;LUO Liang-tao;TAN Hai-yang;YAN Xiang-yuan(Department of General Surgery, the First People＇s Hospital of Tianmen, Tianmen 431700, China)
出处
《现代药物与临床》
CAS
2018年第4期876-879,共4页
Drugs & Clinic
