摘要
目的探讨是否吸烟、是否饮酒、不同居住地特发性膜性肾病(IMN)患者的临床特点。方法收集72例经皮肾穿刺活检确诊为IMN患者的临床资料,包括性别、年龄、血压[收缩压(SBP)、舒张压(DBP)]、吸烟、饮酒、居住地等一般资料,以及血浆白蛋白(ALB)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、血肌酐(SCr)、尿素氮(BUN)、尿酸(UA)、血钙、免疫球蛋白(Ig A、Ig G、Ig M)、C3、C4、24 h尿蛋白定量和肾小球滤过率(e GFR)。分析是否吸烟、是否饮酒、不同居住地IMN患者的临床特点。结果 IMN患者中吸烟者的男性比例、24 h蛋白尿定量均高于不吸烟者(P均<0.01),ALB水平低于不吸烟者(P<0.05)。IMN患者中饮酒者的男性比例、DBP水平均高于不饮酒者(P<0.05或0.01),血钙、Ig G、补体C3水平低于不饮酒者(P<0.05或0.01)。IMN患者中农村患者的DBP水平高于城镇患者(P<0.05),年龄、血清Ig G、Ig A水平低于城镇患者(P<0.05或0.01)。结论 IMN患者中吸烟、饮酒者以男性较多,且吸烟、饮酒及居住地为农村的IMN患者易出现免疫功能下降。
Objective To investigate the clinical features of idiopathic membranous nephropathy（ IMN） patients with or without smoking,drinking alcohol,or living in different places. Methods The clinical data of 72 patients with IMN diagnosed by percutaneous renal biopsy were collected,including gender,age,blood pressure [systolic blood pressure（ SBP）,diastolic blood pressure（ DBP） ],smoking,drinking,and place of residence,and plasma albumin（ ALB）,total cholesterol（ TC）,triglyceride（ TG）,high-density lipoprotein cholesterol（ HDL-C）,low-density lipoprotein cholesterol（ LDL-C）,serum creatinine（ SCr）,blood urea nitrogen（ BUN）,uric acid（ UA）,serum calcium,immunoglobulin（ Ig A,Ig G,Ig M）,complement 3（ C3）,complement 4（ C4）,24-hour urine protein,and glomerular filtration rate（ e GFR）. After that,we analyzed the clinical features of IMN patients who smoked or did not smoke,drank or did not drink and lived in different places. Results Among patients with IMN,the proportion of males and 24-hour urine protein level in smokers were higher than those in non-smokers（ P〈0. 01）,but the ALB level was lower than that of non-smokers（ P〈0. 05）. Compared with non-drinkers,the drinkers had significantly higher proportion of males and DBP level（ P〈0. 05 or P〈0. 01）,while its serum calcium,Ig G and C3 levels were lower（ P〈0. 05 or P〈0. 01）. The rural patients had a significantly higher DBP level as compared with the urban patients（ P〈0. 05）,whereas the age and the levels of Ig G and Ig A were lower than those of the urban patients（ P〈0. 05 or P〈0. 01）. Conclusion Smokers and drinkers of patients with IMN are commonly seen in male,and the patients with IMN who smoke,drink and live in the rural areas are prone to decline in the immune function.
作者
卢华
林能波
曹灵
LU Hua;LIN Nengbo;CAO Ling(The Affiliated Hospital of Southwest Medical University,Luzhou 646000,China)
出处
《山东医药》
CAS
2018年第14期17-20,共4页
Shandong Medical Journal
基金
四川省卫生厅科研基金资助项目(120342)
四川省泸州市科技计划项目(2017LZXNYD-J13)
关键词
特发性膜性肾病
吸烟
饮酒
居住地
男性
免疫功能
idiopathic menlbranous nephropathy
smoking
drinking
place of residence
male
inmmnity
