摘要
目的：整理及分析民族药地稔的研究文献,概述其论文分布、化学成分、药理活性、质量控制、临床应用与专利获批状况,为地稔的临床应用和进一步的开发利用提供参考依据及文献资料。方法：以＂中国知网＂与＂Pubmed＂作检索平台,＂关键词＂、＂摘要＂为检索项,分别以＂地稔＂,＂地菍＂,＂嘎狗噜＂,＂Melastoma dodecandrum Lour.＂和＂Melastoma dodecandrum＂作检索词,检索地稔1973—2017年间国内外的论文报道与专利获批情况。结果：共得论文119篇,专利139项,论文内容以农林栽培、化学成分、质量控制和药理活性研究为主,专利以复方居多。目前从地稔中分离鉴定了83个化学成分,其中以黄酮类为主。质量控制指标多为没食子酸、槲皮素等成分,药理活性以降血糖作用研究居多。结论：地稔的止血作用显著,资源丰富,极具市场竞争力,但地方标准检查项不全,含量测定缺乏专属性指标评价药材优劣,需深入探索地稔止血的作用机制,研究其活性物质基础,建立谱效关系,从而控制地稔药材质量,利于天然药物资源的利用与开发。
Objective： To collect and analyze the reported literature of Melastoma dodecandrum,summarize the paper distribution, chemical compositions, pharmacological activity, quality control, clinical application and patent application status,and provide reference and literature for its clinical application and further development. Method： With ＂CNKI＂and ＂Pubmed＂as the search platform, ＂key words＂and ＂abstract＂as search terms,＂diren＂,＂gagoulu＂,＂Melastoma dodecandrum Lour. ＂and ＂M. dodecandrum＂as search words,the papers and patents of M. dodecandrum at home and abroad from 1973 to 2017 were retrieved in this study.Result： 119 papers and 139 patents were obtained,mainly about agriculture and forestry cultivation,chemical composition,quality control and pharmacological activity research in papers,and mainly about compound products in patents. At present,83 chemical constituents were isolated and identified from M. dodecandrum, mainly including flavonoids. Quality control indicators mainly included gallic acid, quercetin and so on, and the pharmacological research was mainly on hypoglycemic effect. Conclusion： M. dodecandrum had significant hemostatic effects with rich resource and high market competitiveness. However, the local standards were not complete,lacking specific indicators to evaluate the quality of medicinal herbs. Therefore,it is necessary to explore the mechanism of hemostasis in depth, study the basis of its active substances, and establish the relationship between spectrum efficiency and efficacy so as to control the quality of medicinal herbs,and promote the utilization and development of natural medicine resources.
作者
明惠仪
麻秀萍
杨菁
汪娥
MING Hui-yi;MA Xiu-ping;YANG Jing;WANG E(Guiyang University of Chinese Medicine, Guiyang 550002, Chin)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2018年第11期228-234,共7页
Chinese Journal of Experimental Traditional Medical Formulae
基金
苗族医学研究协同创新中心项目(黔教合协同创新字[2015]05)
贵州省食品药品监督管理局项目
国家工程技术研究中心组建项目(2014FU125Q09)
关键词
地稔
文献分布
专利
研究现状
清热解毒
Melastoma dodecandrum
literature distribution
patent
research status
clearing heatand removing toxicity
