摘要
微小RNA(microRNA,miRNA)属于一类小非编码RNA,可以通过作用于目标信使RNA(messenger RNA,mRNA)来调控生物进程。miRNA具有作为肿瘤生物标志物和药物作用靶点的潜能,因此阐明其在肿瘤发生发展中的作用机制十分重要。口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)是一种常见的口腔恶性肿瘤,预后不良。该文对miRNA在OSCC中的生物学功能,相关表达谱改变,调控机制和临床应用前景作一综述。
MicroRNAs（ miRNAs） are a group of small non-coding RNAs that regulate biological process through messenger RNAs（ mRNAs） degradation or translational repression. Because of the role as tumor biomarker and therapeutic target,miRNA is now essential to understanding the molecular mechanism of cancer initiation and progression. Oral squamous cell carcinoma（ OSCC） is a common worldwide cancer causing numerous deaths with a very poor prognosis. This review highlights miRNA functions,alterations in gene expression profile,mechanisms of regulation and clinical applications in OSCC.
作者
杨宗澄
闫广兴
王若琳
徐欣
YANG Zongcheng, YAN Guangxing, WANG Ruolin, XU Xin.(Department of Dental Implant, Stomatology Hospital of Shandong Uni- versity, Ji＇nan 250012, Chin)
出处
《口腔医学》
CAS
2018年第5期476-480,共5页
Stomatology
