摘要
目的探讨血清肿瘤标志物胃泌素释放肽前体(Pro GRP)和神经特异性烯醇化酶(NSE)在小细胞肺癌(SCLC)辅助诊断以及疗效评价中的意义。方法选择2015年1月—2017年3月中山大学附属肿瘤医院初次经病理诊断为SCLC患者127例作为SCLC组,同期正常体检者127例作为正常体检组,同期初次经病理诊断的非小细胞肺癌(NSCLC)患者127例作为NSCLC组,观察3组血清Pro GRP、NSE水平及二者诊断SCLC的价值与预后的关系。结果NSCLC组Pro GRP和NSE水平均高于正常体检组(P<0.05),SCLC组Pro GRP和NSE水平均高于正常体检组和NSCLC组(P<0.05)。广泛期SCLC患者Pro GRP和NSE水平与局限期比较均显著升高(P<0.05)。Pro GRP和NSE均阳性(阳性指≥最佳截断值)诊断SCLC的特异性高于单纯Pro GRP和NSE(P<0.05),Pro GRP和NSE之一阳性诊断SCLC的灵敏度高于Pro GRP和NSE(P<0.05)。治疗无效者Pro GRP和NSE水平均显著高于治疗有效者(P<0.05)。结论检测血清Pro GRP和NSE有助于SCLC诊断,对SCLC化疗疗效具有预测价值,值得临床推广应用。
Objective To investigate significances of serum pro-gastrin releasing peptide（ Pro GRP） and neuron specific enolase（ NSE） in auxiliary diagnosis and evaluation of curative effect of small cell lung cancer（ SCLC）. Methods A total of 127 SCLC patients primitively diagnosed by pathologic results during January 2015 and March 2017 were selected as group A,and other 127 healthy people taking physical examination at the same period were selected as group B,and other 127 patients with non-small cell lung cancer（ NSCLC） by initial pathologic diagnosis at the same period were selected as group C. In three groups,serum Pro GRP and NSE levels were observed,and values and correlations with prognosis of Pro GRP and NSE levels in diagnosis of SCLC were analyzed. Results Pro GRP and NSE levels in group C were significantly higher than those in group B（ P〈0. 05）,and Pro GRP and NSE levels in group A were significantly higher than those in group B and C（ P〈0. 05）. Pro GRP and NSE levels of SCLC patients with extensive stage were significantly increased compared with those of SCLC patients with limitations period（ P〈0. 05）. Specificity of both positive Pro GR and NSE（ positive values≥the optimal cut-off value） in diagnosis of SCLC were significantly better than those by only positive Pro GRP or NSE（ P〈0. 05）,while sensitivity of only positive Pro GRP or NSE in diagnosis of SCLC was significantly better than that by both positive Pro GR and NSE（ P〈0. 05）. Pro GRP and NSE levels in invalid patients were significantly higher than those in effective patients（ P〈0. 05）. Conclusion Detection of serum Pro GRP and NSE levels are helpful for diagnosis of SCLC,and curative effect of chemotherapy on SCLC has predictive value.
作者
彭雄文
沈乐园
宋仕聪
PENG Xiong-wen;SHEN Le-yuan;SONG Shi-cong(Department of Hematologic Neoplasms,Sun Yat-sen Cancer Center,Guangzhou 510060,China;Department of Clinical Laboratory,General Hospital of Guangzhou Military Area Command,Guangzhou 510010,China)
出处
《解放军医药杂志》
CAS
2018年第5期15-18,共4页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
基金
广东省自然科学基金(2016A030313755)
关键词
小细胞肺癌
胃泌素释放肽
神经特异性烯醇化酶
Small cell lung carcinoma
Gastrin releasing peptide
Neuron specific enolase
