摘要
目的探讨中药消痤汤治疗寻常痤疮的效果及对皮损区炎症因子水平的影响。方法将110例寻常痤疮患者应用随机数字表法分为观察组和对照组,每组各55例。两组均予以美满环素+维A酸乳膏治疗,观察组在此基础上加用中药消痤汤。比较两组疗效,评估治疗前、治疗3d后皮损区炎症因子水平[白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)],比较两组治疗前、治疗4周后中医证候积分及生活质量[面部痤疮特异性生活质量调查问卷(QOL-acne)],并记录随访3个月患者复发情况。结果 (1)治疗4周后,观察组临床疗效优于对照组(P<0.05);(2)治疗前,两组皮损区IL-6、IL-8、TNF-α水平差异均无统计学意义(P>0.05);治疗3d后,两组皮损区IL-6、IL-8、TNF-α水平均低于治疗前(P<0.001),观察组降幅大于对照组(P<0.001);(3)治疗前,两组中医证候积分和QOL-acne得分差异均无统计学意义(P>0.05);治疗4周后,两组中医证候积分和QOL-acne得分均低于治疗前(P<0.001或P<0.05),观察组降幅大于对照组(P<0.001或P<0.05);(4)观察组治疗有效者复发率低于对照组(P<0.05)。结论中药消痤汤联合西药治疗寻常痤疮效果良好且复发率较低,且有利于降低患者证候积分、改善其生活质量,临床应用价值可观。
Objective To explore the effects of traditional Chinese drug（TCD）Xiaocuo decoction on acne vulgaris and its influences on the levels of inflammatory factors in the skin lesion area. Methods A total of110 cases of patients with acne vulgaris were divided into an observation group（n =55）and a control group（n=55）according to the random number table method.Both of the two groups were treated with minocycline and tretinoin cream,in addition,the observation group was supplemented with Xiaocuo decoction（TCD）.The efficacy between the two groups were compared.The inflammatory factors[interleukin-6（IL-6）,interleukin-8（IL-8）,tumor necrosis factorα（TNF-α）]in the skin lesion area before treatment and after 3-day treatment,and the traditional Chinese medicine（TCM）syndromes scores and quality of life scores[facial acne specific quality of life questionnaire（QOL-acne）]before treatment and after 4-week treatment were evaluated in the two groups.The recurrence conditions were recorded during 3-month follow-up. Results（1）After 4 weeks of treatment,the clinical efficacy of the observation group was better than that of the control group（P〈0.05）.（2） There were no significant differences between two groups in the levels of IL-6,IL-8 and TNF-αin the skin lesion area before treatment（P〉0.05）,and the above levels after 3-day treatment were lower than those before treatment（P〈0.001）,and the reduction rate in observation group was higher than that in control group（P〈0.001）.（3）There were no significant differences between the two groups in the scores of TCM syndromes and QOL-acne before treatment（P〉0.05）,and the scores of TCM syndromes and QOL-acne after 4-week treatment in the two groups were lower than those before treatment（P〈0.001 or P〈0.05）,and the reduction rates in the observation group were higher than those in the control group（P〈0.001 or P〈0.05）.（4）The recurrence rate of the observation group was lower than that of the control group（P〈0.05）. ConclusionXiaocuo decoction（TCD）combined with western medicine can have good effects and low recurrence rate in treating acne vulgaris,and it is beneficial to reduce the syndromes scores and improve the quality of life,and it has considerably clinical application values.
作者
陈力槟
林笑娟
黄鸿健
Chen Libing;Lin Xiaojuan;Huang Hongjian(Longyan Hospital of Traditional Chinese Medicine,Longyan 364000,Fujian,Chin)
出处
《右江民族医学院学报》
2018年第2期157-160,共4页
Journal of Youjiang Medical University for Nationalities
关键词
消痤汤(中药)
寻常痤疮
炎症因子
Xiaocuo decoction （TCD）
acne vulgaris
inflammatory factors
