期刊文献+

索拉菲尼联合阿霉素治疗晚期胰腺癌患者的疗效

下载PDF
导出
摘要 目的观察索拉菲尼联合阿霉素治疗晚期胰腺癌患者的疗效。方法选取2014年5月至2016年7月医院收治的64例晚期胰腺癌患者为研究对象,随机分为试验组和对照组,每组32例。对照组予以阿霉素单纯治疗,试验组予以阿霉素联合索拉菲尼治疗,比较治疗后两组的临床疗效。结果对照组近期疗效为12.50%,试验组为37.50%,试验组近期疗效显著高于对照组(P<0.05);经1年随访,对照组中位无进展生存期为2.9个月;总生存期为5.4个月。试验组中位无进展生存期为3.3个月,总生存期为6.3个月。两组比较差异有统计学意义(P<0.05)。试验组皮疹发病率高于对照组(P<0.05);试验组白细胞降低、腹泻等不良反应发生率低于对照组(P<0.05)。结论对晚期胰腺癌患者予以阿霉素联合索拉菲尼治疗,能将患者的无进展生存期、总生存期延长,对不良反应具有一定的耐受性。
作者 卢彪
机构地区 修水县中医院
出处 《医疗装备》 2018年第10期129-130,共2页 Medical Equipment
  • 相关文献

参考文献3

二级参考文献23

  • 1JEMAL A, BRAY F, CENTER M M, et al. Global cancerstatistics [ J ] . CA Cancer J Clin, 2011, 61(2): 69-90.
  • 2FERLAY J, PARKIN D M, STELIAROVA-FOUCHER E.Estimates of cancer incidence and mortality in Europe in 2008[J ] . Eur J Cancer, 2010,46(4): 765-781.
  • 3WILHELM S M, CARTER C, TANG L, et al. BAY 43-9006exhibits broad spectrum oral antitumor activity and targetsthe RAF/MEK/ERK pathway and receptor tyrosine kinasesinvolved in tumor progression and angiogenesis [ J ] . CancerRes, 2004, 64(19): 7099-7109.
  • 4DOWNWARD J. Targeting RAS signalling pathways in cancertherapy [ J ] . Nat Rev Cancer, 2003, 3(1): 11-22.
  • 5KANE R C, FARRELL A T, SABER H, et al. Sorafenib for thetreatment of advanced renal cell carcinoma [ J ] . Clin CancerRes, 2006, 12(24): 7271-7278.
  • 6HAUSENLOY D J,MOCANU M M, YELLON D M. Cross-talk between the survival kinases during early reperfusion: itscontribution to ischemic preconditioning [ J ] . CardiovascRes, 2004, 63(2): 305-312.
  • 7NAEGELE S, MORLEY S J. Molecular cross-talk betweenMEK1/2 and mTOR signaling during recovery of 293 cellsfrom hypertonic stress [ J ] . J Biol Chem, 2004, 279(44):46023-46034.
  • 8NOGUCHI R, YOSHIJI H, IKENAKA Y, et al. Synergisticinhibitory effect of gemcitabine and angiotensin type-1receptor blocker, losartan, on murine pancreatic tumor growthvia anti-angiogenic activities [ J ] . Oncol Rep, 2009,22(2):355-360.
  • 9MATSUO Y, SAWAI H, OCHI N, et al. Proteasome inhibitorMG132 inhibits angiogenesis in pancreatic cancer by blockingNF-kappaB activity [ J ] . Dig Dis Sci, 2010,55(4): 1167-1176.
  • 10史艳侠,徐瑞华,姜文奇,张力,林桐榆,李宇红,夏忠军,骆卉研,韩冰,王峰,何友兼,管忠震.吉西他滨联合奥沙利铂治疗晚期胰腺癌患者的疗效[J].癌症,2007,26(12):1381-1384. 被引量:11

共引文献3

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部