摘要
以林蛙皮和人参为主要原料设计了一种林蛙皮-人参美白保湿膏剂,以膏剂的外观、耐寒性、耐热性、乳化性和离心稳定性为评价指标,利用单因素实验、Box-Benhnken中心组合设计原理和响应面分析法研究硬脂酸、单硬脂酸甘油酯、甘油的添加量对膏剂的影响.研究结果显示,膏剂的最佳基质配比为:硬脂酸8%、单硬脂酸甘油酯1.5%、甘油12%,最佳基质组成配方的综合评分为9.34.该结果说明响应面法优化可有效提高林蛙皮-人参美白保湿膏剂的综合评分,且方法准确可行.
Rana chensinensis skin and Panax ginseng was used as the main raw material to design Rana chensinensis skin-Panax ginseng whitening moisturizing cream, the addition quantity effect of stearic acid, glyceryl monostearate and glycerine was analyzed using single factor experiment, Box-behnken design and response surface method, to take the appearance, cold resistance, heat resistance, emulsification and centrifugal stability as index. The optimal formula was stearic acid（8%）, glyceryl monostearate（1.5%）, glycerin（12%）, the comprehensive score of the optimal matrix composition was 9.34. This imply the response surface methods were proved to enhance the comprehensive score of Rana chensinensis skin-Panax ginseng whitening and moisturizing cream, and the method is accurate and feasible.
作者
衣铭慧
孙志双
施溯筠
YI Minghui;SUN Zhishuang;SHI Suyun(College of Pharmacy, Yanbian University, Yanji 133002, China)
出处
《延边大学学报（自然科学版）》
CAS
2018年第1期58-62,共5页
Journal of Yanbian University（Natural Science Edition）
关键词
响应面法
基质配方
林蛙皮
人参
response surface method
matrix formula
Rana chensinensis skin
Panax ginseng
