摘要
目的探讨布地奈德联合沙丁胺醇治疗支气管哮喘的临床疗效及其对患者肺功能的影响。方法选取湖北省恩施土家族苗族自治州来凤县旧司镇中心卫生院2015年6月—2016年12月收治的支气管哮喘患者116例,随机分为对照组和观察组,各58例。对照组患者采用沙丁胺醇治疗,观察组患者在对照组基础上加用布地奈德治疗,两组患者均持续治疗2周。比较两组患者的临床疗效及肺通气功能指标[第1秒用力呼气末容积(FEV1)、用力肺活量占预计值百分比(FVC%)、呼气峰值流速(PEF)昼夜变异率]。结果观察组患者临床疗效优于对照组(P<0.05)。治疗前,两组患者FEV1、FVC%和PEF昼夜变异率比较,差异无统计学意义(P>0.05);治疗后,观察组患者FEV1、FVC%高于对照组,PEF昼夜变异率低于对照组(P<0.05)。结论采用布地奈德联合沙丁胺醇治疗支气管哮喘的临床疗效确切,可有效改善患者的肺通气功能。
Objective To discuss the clinical effect of budesonide combined with salbutamol in treating bronchial asthma and the impact on pulmonary ventilation function.Methods A total of 116 cases of patients with bronchial asthma were selected from June 2015 to December 2016 in Hubei Province Enshi Tujia and Miao Autonomous Prefecture Laifeng County Old Town Center Health Center,which were randomly divided into control group and observation group,58 cases in each group.The control group was treated with salbutamol,the observation group was treated with budesonide on the basis of control group,the two groups were treated for 2 weeks.The clinical effect and pulmonary ventilation function indicators（FEV1,FVC,PEF diurnal variation rate） were compared between the two groups.Results The clinical efficacy of the observation group was better than control group（P〈0.05）.Before treatment,no significant differences of FEV1,FVC or PEF diurnal variation rate was found between the two groups（P〉0.05）;after treatment,the observation group of FEV1,FVC were higher than control group,PEF diurnal variation rate was lower than control group（P〈0.05）.Conlusion Budesonide combined with salbutamol have an exactly clinical effect in treating bronchial asthma,it can effectively improve pulmonary ventilation function of patients.
作者
梁新玉
LIANG Xin-yu(Hubei Province Enshi Tujia and Miao Autonomous Prefecture Laifeng County Old Town Center Health Center, Laifeng 445705, Chin)
出处
《临床合理用药杂志》
2018年第12期1-2,共2页
Chinese Journal of Clinical Rational Drug Use
关键词
哮喘
布地奈德
沙丁胺醇
肺通气功能
治疗结果
Asthma
Budesonide
Salbutamol
Pulmonary ventilation function
Treatment outcome
