摘要
目的观察更昔洛韦眼用凝胶联合氟米龙治疗单疱病毒性角膜炎(HSK)的临床疗效。方法选取2014年3月-2016年4月医院诊治的HSK患者50例(59眼),根据治疗方式不同分为观察组25例(30眼)与对照组25例(29眼)。观察组给予更昔洛韦眼用凝胶联合0.02%氟米龙治疗,对照组给予阿昔洛韦滴眼液治疗,2组疗程均为14 d,比较2组治疗效果、视力及复发情况。结果观察组总有效率为88.00%高于对照组的68.00%,差异有统计学意义(P<0.05)。治疗后2组患者的视力均优于治疗前,且观察组患者的视力优于对照组,差异有统计学意义(P<0.05)。选取2组患者中治疗有效者随访1年,观察组的复发率明显低于对照组,差异有统计学意义(P<0.05)。结论更昔洛韦眼用凝胶联合氟米龙治疗HSK疗效好,值得推广。
Objective To observe the clinical efficacy of ganciclovir eye gel combined with fluorometholone in the treatment of herpes simplex keratitis(HSK）. Methods Selected 50 cases(59 eyes） of HSK patients admitted to the hospital from March 2014 to April 2016. According to different treatment methods divided into observation group 25 cases(30 eyes） and control group 25 cases(29 eyes）. Observation group was given ganciclovir ophthalmic gel in combination with 0. 02% fluorometholone,and control group was given acyclovir ophthalmic solution. The course of treatment in both groups was 14 days. The treatment effects,visual acuity and recurrence of two groups were compared. Results The total effective rate in observation group was 88. 00% higher than 68. 00% in control group,which was statistically significant(P〈0. 05）. The visual acuity of two groups after treatment was better than before treatment,and the visual acuity of observation group was better than that of control group,and the difference was statistically significant(P〈0. 05）. Patients with effective treatment in 2 groups were followed up for 1 year,the recurrence rate of observation group was significantly lower than that of control group,and the difference was statistically significant(P〈0. 05）. Conclusion Ganciclovir eye gel combined with fluorometholone in the treatment of HSK is effective and worthy of promotion.
作者
邢志芳
XING Zhifang(Department of Ophthalmology, The People＇ s Hospital of Taiyuan City, Shanxi Province, Taiyuan 030000, Chin)
出处
《临床合理用药杂志》
2018年第13期37-38,共2页
Chinese Journal of Clinical Rational Drug Use
关键词
更昔洛韦眼用凝胶
氟米龙
单疱病毒性角膜炎
Ganciclovir ophthalmic gel
Fluorometholone
Herpes simplex virus keratitis
