摘要
目的分析腹腔热灌注化疗对胃癌患者CyclinE基因表达的影响及临床疗效。方法选取2014年1月至2017年5月海安县人民医院收治的胃癌术后患者168例,采用随机数字表法分为对照组和观察组,每组84例。对照组采用常规静脉化疗,观察组采用腹腔热灌注化疗,比较两组患者治疗后的疗效、生存质量、外周血肿瘤标志物含量及肿瘤组织中CyclinE、CyclinB2、CyclinD1基因表达情况。结果观察组患者治疗后完全缓解23例,部分缓解25例,总有效率57.14%,对照组完全缓解12例,部分缓解18例,总有效率35.71%,观察组总有效率高于对照组,差异有显著性(P<0.05)。观察组患者治疗后外周血肿瘤标志物DDK1和EXOSC2表达水平低于对照组,PGII表达水平高于对照组,差异有显著性(P<0.05)。观察组患者治疗后肿瘤组织中CyclinE、CyclinB2及CyclinD1基因表达水平低于对照组(P<0.05),总体生活质量高于对照组(P<0.05)。结论腹腔热灌注化疗治疗胃癌术后患者疗效明显,可杀灭胃癌细胞,减少肿瘤标志物释放入血,抑制细胞周期,改善患者生存质量。
Objective To analyze the effect of intraperitoneal hyperthermic perfusion chemotherapy on the expression of CyclinE gene and clinical efficacy in patients with gastric cancer. Method 168 patients were selected from January 2014 to May 2017 in our hospital after gastric cancer surgery, divided into control group and observation group randomly. The control group was treated with conventional chemotherapy treatment, the observation group were treated by intraperitoneal hyperthermic perfusion chemotherapy treatment. The curative effect was observed after treatment in two groups, quality of survival, tumor markers and CyclinE. CyclinB2 and CyclinD1 expression. Result 23 cases of CR patients in the observation group, 25 cases of PR, the total efficiency of 57.14%; control group CR 12 cases, PR 18 cases, the total efficiency of 35.71%; the total efficiency of the observation group is higher than that of control group （P〈0.05）. Peripheral blood DDK1 and EXOSC2 levels after treatment in the observation group were lower than the control group, the level of PGII higher than that of the control group （P〈0.05）. To observe the gene CyclinE tumor group after treatment, CyclinB2 and CyclinD1 levels lower than the control group （P〈0.05）. Patients in the observation group after treatment in general The quality of life was higher than that in the control group （P〈0.05）. Conclusion Intraperitoneal hyperthermic perfusion chemotherapy is effective in the treatment of gastric cancer. It can kill gastric cancer cells, reduce tumor markers release into the blood, inhibit cell cycle, and improve the quality of life of patients.
作者
仲思恂
茅国新
鲁小敏
张燕
钱烨
ZHONG Si-xun;MAO Guo-xin;LU Xiao-min;ZHANG Yan;QIAN Ye(Department of Oncology, People＇s Hospital of Haian, Jiangsu Haia. n 226600, China;Department of Oneology, Affiliated Hospital of Nantong University, Jiangsu Nantong 226001, China)
出处
《中国医刊》
CAS
2018年第5期507-510,共4页
Chinese Journal of Medicine
关键词
腹腔热灌注化疗
胃癌
肿瘤标志物
CyclinE基因
生存质量
Intraperitoneal hyperthermic perfusion chemotherapy
Stomach cancer
Tumor marker
CyclinE gene
Quality of life
