摘要
[目的]观察芪药消渴胶囊联合健康教育+西药治疗糖尿病肾病早期尿蛋白疗效。[方法]使用随机平行对照方法,将56例住院患者按病志号抽签随机分两组。对照组28例健康教育、饮食控制以及胰岛素等常规治疗方法;瑞格列奈,1mg/次,3次/d;依那普利,10mg/次,2次/d。治疗组28例芪药消渴胶囊(西洋参、地黄生、山茱萸、麦门冬、天花粉、五味子及五倍子等),6粒/次,3次/d;健康教育及西药治疗同对照组。连续治疗1个月为1疗程。观测临床症状、24h尿蛋白排泄率、不良反应。连续治疗3疗程,判定疗效。[结果]治疗组显效16例,有效10例,无效2例,总有效率92.86%;对照组显效12例,有效8例,无效8例,总有效率71.43%;治疗组疗效优于对照组(P<0.05)。24h尿蛋白排泄率改善治疗组优于对照组(P<0.05)。[结论]芪药消渴胶囊联合健康教育+西药治疗糖尿病肾病早期尿蛋白,疗效满意,无严重不良反应,值得推广。
[[Objective] To observe the therapeutic effect of Qiyaoxiaoke capsules combined with health education＋western medicine for diabetic nephropathy（DN） with early diabetic nephropathy. [Methods] we used random parallel control method, 56 inpatients were randomly divided into two groups according to the number of disease records. 28 cases of health education, diet control and insulin and other conventional treatment was control group; repaglinide, 1 mg/times, 3 times/d; enalapril, 10 mg/times, 2 times/d. In the treatment group, 28 cases of Qiyaoxiaoke Capsule（Radix quinquefolium, Rehmannia glutinosa, Cornus officinalis, trichosanthin, Schisandra, Schisandra and gallnut）, 6 grains/times, and 3 times/d, health education and western medicine treatment were the same as the control group. Continuous treatment for 1 months was the 1 course of treatment. Observe clinical symptoms, 24 h urinary protein excretion rate and adverse reactions. The 3 course of treatment was continuously treated to determine the curative effect. [Results] in the treatment group, 16 cases were obviously effective, 10 cases were effective, 2 cases were invalid, the total effective rate was 92.86%, in the control group, 16 cases were obviously effective, 8 cases were effective, 8 cases were invalid and the total effective rate was 71.43%. The curative effect of the treatment group was better than the control group（P〈0.05）. 24 h urinary protein excretion rate in the treatment group was better than that in the control group（P〈0.05）. [Conclusion] Qiyaoxiaoke Capsule Combined with health education＋western medicine has satisfactory effect in the treatment of early diabetic nephropathy with albuminuria. There is no serious adverse reaction, and t is worth promoting.
作者
刘波
ZHANG Quanwen;DOU Jinming(Zhoukou City Hospital of Traditional Chinese Medicine Department of Nephrology Diabetes,Zhoukou 46600,Henan,Chin)
出处
《实用中医内科杂志》
2018年第4期25-27,共3页
Journal of Practical Traditional Chinese Internal Medicine
关键词
早期尿蛋白
糖尿病肾病
芪药消渴胶囊
瑞格列奈
依那普利
24h尿蛋白排泄率
健康教育
中药复方
中西医结合治疗
随机平行对照研究
early albuminuria
diabetic nephropathy
Qiyaoxiaoke capsule（芪药消渴胶囊）
reagenet
enalapril
24h urine protein excretion rate
health education
Chinese medicine compound
combination of traditional Chinese and western medicine
randomized parallel control study
