摘要
目的探讨整体护理在HCV感染合并肝功能异常患者抗病毒治疗中的应用效果。方法选取2013年1月-2016年1月医院收治的肝功能异常合并HCV感染患者162例,抗病毒治疗的同时,按随机数字表法分为对照组和试验组,各81例;对照组患者行常规护理,试验组患者行整体护理,治疗48周后观察两组患者治疗前后肝功能变化,指标包括丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、血清白蛋白(ALB)、总胆红素(Total TBIL),同时观察两组早期病毒学应答(EVR)、治疗结束时病毒学应答(ETVR)、持续应答(SVR)、复发情况及不良反应发生情况,并采用健康调查简表(SF-36)对患者生活质量进行评定。结果两组患者抗病毒治疗后肝功能指标ALT、AST、ALB、TBIL水平较治疗前均降低,且两组水平比较差异无统计学意义;生活质量各指标评分均升高,两组比较差异有统计学意义(P<0.05);两组患者免疫应答:EVR、ETVR、SVR及复发率比较差异无统计学意义;不良反应有白细胞下降、血小板减少、乏力等。结论对肝功能异常合并HCV感染患者进行抗病毒治疗的同时,实施整体护理干预,可缓解患者病情,同时提高患者生活质量。
OBJECTIVE To explore the effect of holistic nursing on antiviral treatment of HCV infection patients complicated with abnormal liver function.METHODS A total of 162 abnormal liver function patients complicated with HCV infection who were treated in the hospital from Jan 2013 to Jan 2016 were enrolled in the study and were given the antiviral therapy.The patients were randomly divided into the control group and the experimental group,with 81 cases in each group,and the patients were treated for 48 weeks in total.The control group was treated with conventinal nursing,while the experimental group was given the holistic nursing.The liver function indexes,including the alanine aminotransferase（ALT）,aspartate aminotransferase（AST）,serum albumin（ALB）and total bilirubin（TBIL）,were observed and compared between the two groups of patients before and after the treatment;the early virologic response（EVR）,virological response at the end of treatment（ETVR）,sustained response（SR）,recurrence rate and incidence of adverse reactions were observed and compared between the two groups of patients.The quality of life of the patients was evaluated by using short form health survey（SF-36）.RESULTS The levels of liver function indexes ALT,AST,ALB and TBIL of the two groups of patients were lower after the antiviral therapy than before the antiviral therapy,however,there were no significant differences between the two groups.The scores of the life quality indexes were increased,and there were significant differences（P0.05）.There were no significant differences in the EVR,ETVR,SVR and recurrence rate between the two groups of patients.The incidence rate of adverse reactions of the experimental group was 7.41%,significantly lower than 23.46% of the control group（P0.05）.CONCLUSION The holistic nursing intervention combined with antiviral therapy may alleviate the illness condition of the abnormal liver function patients complicated with HCV infection,reduce the incidence of adverse reactions and raise the quality of life.
作者
陈瑾
饶高峰
陈林平
应丽勤
陈晓莉
CHEN Jin;RAO Gao-feng;CHEN Lin-ping;YING Li-qin;CHEN Xiao-li(Wenling First People＇s Hospital, Taizhou, Zhejiang 317500, China)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2018年第9期1363-1366,共4页
Chinese Journal of Nosocomiology
基金
浙江省医药卫生科技计划基金资助项目(2010KYA188)
关键词
肝功能异常
HCV感染
抗病毒
整体护理
Abnormal liver function
HCV infection
Antiviral
Holistic nursing
