摘要
目的：探讨心理疗法联合药物干预对青年卒中后睡眠障碍患者精神心理状态、细胞因子表达水平及预后效果的影响。方法：以2015年2月-2017年3月我院收治的78例青年卒中后睡眠障碍患者为对象,采用随机数字表法均分为对照组和联合组,对照组实施常规药物干预,联合组另实施心理疗法联合药物干预,观察治疗前后两组细胞因子[白细胞介素-1β（IL-1β）、肿瘤坏死因子（TNF-α）]、精神心理状态[焦虑自评量表（SAS）、抑郁自评量表（SDS）]、睡眠质量[睡眠潜伏期（SL）、总睡眠时间（TST）、觉醒次数（AT）]及美国国立卫生研究院卒中量表（NIHSS）评分变化。结果：与治疗前相较,治疗后两组IL-1β、TNF-α、SAS、SDS、SL、AT评分及NIHSS评分明显降低,而TST明显升高,差异显著（t研究组=16.481,21.578,13.721,32.105,10.249,19.590;t对照组=9.606,10.710,6.748,21.379,3.748,7.177,4.551,11.240;P〈0.001）;并且治疗后联合组的各项指标变化较对照组明显,差异有统计学意义（t=9.226,12.752,7.985,12.751,3.178,7.095,5.945,9.284;P〈0.001）。结论：心理疗法联合药物干预治疗青年卒中后睡眠障碍患者时,可有效改善患者精神心理状态、降低细胞因子表达水平,并明显改善患者睡眠质量及预后效果。
Objective：To explore the effect of psychotherapy combined with drug intervention on the mental status,expression levels of cytokines and the prognosis of patients with post-stroke sleep disorders.Methods：A total of 78 young patients with post-stroke sleep disorders treated in our hospital from February 2015 to March 2017 were selected as subjects and they were randomly divided into the control group and the combined group by random number table method.The control group were given routine drug intervention,and the combined group were given psychotherapy combined with drug intervention.Changes of cytokines[interleukin-1β（IL-1β）,tumor necrosis factor alpha（TNF-α）],the mental statues[Self-rating Anxiety Scale（SAS）,Self-rating Depression Scale（SDS）],sleep quality[sleep latency（SL）,total sleep time（TST）,awaken times（AT）]and the National Institutes of Health Stroke Scale（NIHSS）scores in the two groups before and after treatment were observed.Results：After treatment,levels of IL-1βand TNF-α,scores of SAS,SDS,SL,AT and NIHSS decreased significantly,and TST increased significantly in the two groups（tcombined group=16.481,21.578,13.721,32.105,10.249,19.590;t control group=9.606,10.710,6.748,21.379,3.748,7.177,4.551,11.240;P〈0.001）.Changes in the above-mentioned indicators were more obvious in the combined group than the control group（t=9.226,12.752,7.985,12.751,3.178,7.095,5.945,9.284,P〈0.001）.Conclusion：Psychotherapy combined with drug intervention can effectively improve the mental statues,reduced the expression levels of cytokines,and significantly improve the sleep quality and prognosis of young patients with post-stroke sleep disorders.
作者
赵岩
ZHAO Yan(The First Affiliated Hospital of Nanyan Medical College ,Nanyang 473000,Chin)
出处
《中国健康心理学杂志》
2018年第5期645-649,共5页
China Journal of Health Psychology
关键词
青年卒中
睡眠障碍
心理疗法
药物干预
精神心理状态
细胞因子
Young patients with stroke
Sleep disorders
Psychotherapy
Drug intervention
Mental status
Cyto-kine
