摘要
目的:比较不同疗程奥美拉唑治疗反流性咽喉炎的疗效及安全性。方法:选取2015-03-2017-01期间收治的160例咽喉反流患者(诊断性治疗8周确诊),随机分为A组、B组、C组、D组,每组40例。每组患者均口服奥美拉唑肠溶胶囊20mg,Bid,疗程分别为1、2、3、4个月。比较4组患者治疗前、疗程结束时及疗程结束后1个月、2个月的反流症状指数量表(RSI)、反流体征指数量表(RFS)评分、24h食管pH值测定及胃蛋白酶检测结果,并评定疗效和不良反应。结果:随着疗程增加,患者的RSI评分、RFS评分、24h食管内pH值<4.0占总时间的百分率、胃蛋白酶阳性率均渐降低,治疗前后差异有统计学意义;治疗后B组和A组、C组和B组差异有统计学意义,D组和C组比较差异无统计学意义;疗程结束后至随访2个月,A组、B组3次RSI、RFS评分渐升高,24h食管内pH值<4.0占总时间的百分率增加,胃蛋白酶阳性率升高(均P>0.05),C组、D组3次RSI评分、RFS评分、24h食管内pH<4.0占总时间的百分率、胃蛋白酶阳性率均差异无统计学意义。随着疗程增加,治疗的有效率增加,分别为67.5%、80.0%、90.0%、95.0%,差异有统计学意义(P<0.05),但不良反应并没有增加(P>0.05)。结论:奥美拉唑治疗咽喉反流安全有效,疗程5个月患者的症状体征明显好转,并且病情相对稳定、复发率较低。
Objective：To compare the efficacy and safety of omeprazole in the treatment of laryngopharyngeal reflux.Method：One hundred and sixty patients with laryngopharyngeal reflux in our hospital from March 2015 to January 2017（diagnosis treatment for 8 weeks）were selected and randomly divided into group A,B,C,D,with40 cases in each group.Each group of patients were treated with omeprazole enteric-coated capsules（20 mg,Bid）for 1,2,3 and 4 months,respectively.The reflux symptom index（RSI）,reflux finding score（RFS）score,and24 hintraesophageal pH-metry,pepsin detection were compared between the four groups before treatment,at the end of treatment,at 1 month and 2 months after treatment.The efficacy and side effects were evaluated.Result：With the increase of treatment course,patient＇s RSI and RFS score,24h pH-metry〈4.0 percentage,pepsin positive rate decreased gradually,and there was a significant difference between before and after treatment.After treatment,there was a statistical significance in group B and group A,group C and group B.There was no significant difference between group D and group C.After the end of treatment and up to 2 months of follow-up,the RSI and RFS scores gradually increased and 24h Ph-metry〈4.0 percentage,pepsin positive rate increased in group A and B,and those were not significantly different in group C and group D.With the increase of treatment duration,the effective rate of treatment increased,which was 67.5%,80.0%,90.0% and 95.0%,respectively.The difference was statistically significant,but the adverse effects did not increase（P〉0.05）.Conclusion：Omeprazole is safe and effective in the treatment of laryngopharyngeal reflux.The symptoms and signs of the patients are obviously improved during the 5 months of the course,and the condition is relatively stable and the recurrence rate is low.
作者
齐智伟
陆鸿略
张洁
张淑君
QI Zhiwei;LU Honglue;ZHANG Jie;ZHANG Shujun(Department of Otorhinolaryngology, Affiliated Hospital of Chengde Medical College, Chengde, 067000, Chin)
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
北大核心
2018年第9期693-697,共5页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery
关键词
咽喉反流
奥美拉唑
疗程
laryngopharyngeal reflux
omeprazole
course
