摘要
目的建立成都地区Beckman试剂妊娠各期甲状腺功能指标正常参考值范围。方法随机抽选2016年11月-2017年6月于成都医学院第一附属医院进行常规产检的445例不同孕期妇女和120例非妊娠妇女,检测其血清游离三碘甲腺原氨酸(free triiodothyronine,FT,)、游离甲状腺素(free thyroxine,FT_4)、促甲状腺激素(thyroid stimulating hormone,TSH),用SPSS 24.0计算其双侧限值(第2.5和97.5百分位数),建立Beckman试剂对应的正常值范围。结果 FT_3、FT_4、TSH在妊娠早、中、晚期参考范围分别为4.41～6.33、4.17～6.12、3.86～6.39 pmol/L,7.64～14.63、6.62～13.69、6.62～12.51 pmol/L,0.21～3.62、0.16～4.35、0.89～4.88 mU/L。除了血清TSH在妊娠早、中期之间差异无统计学意义(P>0.05)及血清FT_3分别在妊娠早期、中期与对照组之间差异无统计学意义(P>0.05),血清FT_3、FT_4、TSH在其余妊娠各期之间,及各期与对照组之间差异均有统计学意义(P<0.05)。妊娠早、中期TSH与FT_4之间分别存在相关性(r=-0.277、-0.392,P<0.01)。结论该研究建立的Beckman试剂妊娠期FT_3、FT_4、TSH的参考值范围,明显不同于非妊娠妇女。
Objective To establish a normal reference value range of specific thyroid function in pregnant women corresponding to Beckman reagent in Chengdu. Methods We randomly selected 120 non-pregnant women and445 pregnant women who underwent routine examinations at the First Affiliated Hospital of Chengdu Medical College from November 2016 to June 2017; tested for free triiodothyronine（FT,）, free thyroxine（FT4）, and thyroid stimulating hormone（TSH） in serum; used SPSS 24.0 to calculate the bilateral limit of each index（Section 2.5, 97. 5 Quot）; established the normal range of Beckman reagent. Results The reference ranges of FT3, FT4, and TSH in the first, second, and third trimester of pregnancy were 4.41-6.33, 4.17-6.12, and 3.86-6.39 pmol/L; 7.64-14.63, 6.62-13.69, and 6.62-12.51 pmol/L;0.21-3.62, 0.16-4.35, and 0.89-4.88 mU/L; respectively. There was no significant difference in serum TSH between the first and second trimester（P〉0.05）, and neither between the first and second trimesters and the controls in serum FT3（P〉0.05）. The differences in serum FT3, FT4, and TSH among the rest of trimesters, and between each trimester and the normal control group were statistically significant（P〈0.05）. There was a significant correlation between TSH and FT4 in the early and middle stages of pregnancy（r=-0.277,-0.392, P〈0.01）. Conclusion The reference value of FT3,FT4, and TSH in pregnant women with Beckman reagent was significantly different from that in non-pregnant women.
作者
梁新颖
黎瑶
李婷
邱平
梅希
LIANG Xinying;LI Yao;LI Ting;QIU Ping;MEI Xi(Department of Endocrinology and Metabolic Disease, the First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610500, P. R. China)
出处
《华西医学》
CAS
2018年第5期527-531,共5页
West China Medical Journal
基金
四川省内分泌代谢病学重点学科建设项目
