摘要
口服给药是最常用,最方便和最安全的一种给药方式,药物经口服后首先被胃肠道吸收进入血液循环之后才能发挥治疗作用,其中药物剂型、处方中药物形态与赋形剂、胃肠道生理状况和食物成分、以及肝首过效应等代谢系统都将会对口服药物的吸收造成影响。特别是食物对口服药物吸收的影响,主要表现为直接影响和间接影响。食物与药物间的这种相互作用最终会导致药物吸收的延缓,减少或者增加,当然也有不影响药物吸收的情况。因此,探讨食物对口服药物吸收的影响非常必要。本文综述了近年来食物对于口服药物吸收和生物利用度的研究进展。
Oral administration is the most commonly used,the most convenient and secure mode of administration of drugs. After oral administration,the drug is first absorbed into the blood circulation to play a therapeutic effect. Many factors,including dosage forms,excipients,gastrointestinal morphology and physiological status,food components,and metabolism system such as the liver first-pass effect may affect the absorption of oral drugs. In particular,the influence of food on oral drug absorption is mainly manifested by direct and indirect effects. The interactions between food and drugs can eventually lead to the delay,decrease,or increase in drug absorption,and of course,it may exist without affecting the absorption of drugs. Therefore,it is necessary to investigate the effects of food on oral drug absorption. In this paper,the recent advances in food absorption and bioavailability of oral drugs are reviewed.
作者
陈艳君
刘梅
靳倩
高春生
CHEN Yan-jun;LIU Mei;JIN Qian;GAO Chun-sheng(Pharmacy College, Henan University, Kaifeng 475000, China;Patent Examination Cooperation Center, SIPO, Tianjin 300304, China;Institute of Pharmacology and Toxicology, Academy of Military Medical Science, Beijing 100850, China)
出处
《中国新药杂志》
CAS
CSCD
北大核心
2018年第10期1137-1143,共7页
Chinese Journal of New Drugs
基金
国家“重大新药创制”科技重大专项资助项目(2017ZX09101-005-008-001)
关键词
口服给药
食物
胃肠道的生理环境
生物利用度
稳定性
oral administration
food
physiological environment in gastrointestinal tract
bioavailability
stability
