摘要
目的探讨丁苯酞联合氯吡格雷对早期脑梗死患者血液黏稠度和经颅多普勒检测参数的影响。方法选取90例脑梗死患者，采取随机数字表法分为对照组和观察组，每组45例。对照组给予口服氯吡格雷，观察组给予氯吡格雷联合丁苯酞。比较两组脑梗死患者的临床疗效、血液黏稠度[全血高切黏度（HSV）、全血低切黏度（LSV）及血浆黏度（PSV）]变化及经颅多普勒超变化。结果观察组总有效率为93.33%，明显高于对照组的73.33%，差异有统计学意义（χ2＝5.67，P〈0.05）。两组治疗后与治疗前相比HSV及PSV均降低（t＝4.34、4.56、7.89、7.23，均P〈0.05），观察组治疗后降低更加显著（t＝6.55、6.67，均P〈0.05）。两组治疗后与治疗前相比ACA及MCA的Vm均升高（t＝4.34、4.90、7.33、6.92，均P〈0.05），ACA及MCA的PI均降低（t＝4.77、4.66、7.12、7.29，均P〈0.05），观察组治疗后与对照组治疗后相比上述指标改善更加显著（t＝6.31、5.50、6.54、6.28，均P〈0.05）。结论采用丁苯酞联合氯吡格雷用于早期脑梗死患者的临床效果显著，能够有效改善血液黏稠度的变化。
ObjectiveTo explore the effects of the combination of butylphthalide and clopidogrel on the blood viscosity and parameters of transcranial Doppler in patients with cerebral infarction.MethodsNinety patients with cerebral infarction were selected, and they were divided into control group and observation group according to the digital table, with 45 cases in each group.The control group was orally given clopidogrel, the observation group was given clopidogrel combined with butylphthalide.The clinical curative effect, blood viscosity changes and transcranial Doppler changes were compared between the two groups.ResultsThe total effective rate of the observation group was 93.33%, which was significantly higher than 73.33% of the control group （χ2=5.67, P〈0.05）. After treatment, the HSV and PSV of the two groups were lower than those before treatment（t=4.34, 4.56, 7.89, 7.23, all P〈0.05）, and the decrease of HSV and PSV in the observation group was more significant than those in the control group after treatment（t=6.55, 6.67, all P〈0.05）. Compared with those before treatment, the Vm of ACA and MCA in the two groups after treatment significantly increased（t=4.34, 4.90, 7.33, 6.92, all P〈0.05）, the PI of ACA and MCA significantly decreased（t=4.77, 4.66, 7.12, 7.29, all P〈0.05）, and the above indicators in the observation group after treatment improved more significantly compared with those in the control group（t=6.31, 5.50, 6.54, 6.28, all P〈0.05）.ConclusionThe effect of the early combination of butylphthalide and clopidogrel in the treatment of patients with cerebral infarction is significant, and it can effectively improve the change of blood viscosity.
作者
陆旭东
金玉华
俞晓翔
沈和平
王琰萍
Lu Xudong;Jin Yuhua;Yu Xiaoxiang;Shen Heping;Wang Yanping.(Department of Neurology, the Second Hospital of Jiaxing, Jiaxing, Zhejiang314000, China)
出处
《中国基层医药》
CAS
2018年第11期1391-1394,共4页
Chinese Journal of Primary Medicine and Pharmacy
基金
浙江省医药卫生科技计划项目（2017KY653）
