摘要
目的观察奥拉西坦、依达拉奉和疏血通三药联合治疗对脑出血患者脑血肿及神经功能的改善情况。方法将96例脑出血患者采用随机数字表法分为观察组和对照组，每组48例。对照组按规范给予常规治疗，观察组在常规治疗基础上予三药联合治疗方案，分别为奥拉西坦（4.0 g加0.9%氯化钠注射液配成250 mL溶液，静脉滴注，1次/d）＋依达拉奉（30 mg加0.9%氯化钠注射液配成100 mL溶液，静脉滴注30 min，2次/d）＋疏血通（4 mL加0.9%氯化钠注射液配成250 mL溶液，静脉滴注，1次/d），治疗21 d后观察两组患者的疗效及安全性。结果两组在神经功能缺损评分和脑血肿体积改善方面均得到了改善（均P〈0.05），但观察组改善情况明显优于对照组[（4.44±3.20）分比（10.53±2.86）分，（21.83±3.85）分比（26.71±3.49）分，（7.83±5.31）mL比（13.74±6.16）mL，t＝9.818、6.506、5.035，均P〈0.01]，临床总有效率高于对照组（87.5%比52.1%，χ2＝14.740，P〈0.05）。两组均未发生药物相关不良反应。结论应用奥拉西坦与依达拉奉和疏血通三药联合治疗脑出血患者可有效改善脑水肿及神经缺损，促进脑出血后患者的恢复，值得临床应用推广。
ObjectiveTo explore the therapeutic effects of edaravone, oxiracetam combined with Shuxuetong on cerebral hematoma and improvement of neurological function in patients with cerebral hemorrhage.MethodsA total of 96 patients with cerebral hemorrhage were randomly divided into observation group and control group by the random number table method, with 48 cases in each group.The observation group received intravenous drip of edaravone （4.0g added into 0.9% sodium chloride injection to 250mL, intravenous drip, 1 time/d）, oxiracetam（30mg added into 0.9% sodium chloride injection to 100mL solution, 30min intravenous drip, 2 times/d）, and Shuxuetong injection（4mL added into 0.9% sodium chloride injection to 250mL, intravenous drip, 1 time/d） on the basis of routine treatment, and the control group was treated with routine treatment for cerebral hemorrhage.The efficacy and safety in the two groups after treatment of 21 days were observed.ResultsAfter treatment, the neurological deficit score and cerebral hematoma volume of the two groups were improved（all P〈0.05）, but the improvements of the observation group was significantly better than those of the control group[（4.44±3.20）points vs.（10.53±2.86）points, （21.83±3.85）points vs.（26.71±3.49）points, （7.83±5.31）mL vs.（13.74±6.16）mL, t=9.818, 6.506, 5.035, all P〈0.01]. The total effective rate of the observation group was higher than that of the control group（87.5% vs.52.1%, χ2=14.740, P〈0.05）. No drug-related adverse reactions occurred in two groups.ConclusionThe application of oxiracetam and edaravone combined with Shuxuetong injection in patients with cerebral hemorrhage can effectively improve the brain edema and nerve defect, it has a positive significance to promote the patients＇ recovery after cerebral hemorrhage, and it is worthy of clinical application.
作者
周辉杰
李悦
王晓蕾
辛月花
柳玉娟
冯立华
Zhou Huifie;Li Yue;Wang Xiaolei;Xin Yuehua;Liu Yujuan;Feng Lihua.(Department of Neurology, the People ＇s Hospital of Haiyang , Haiyang , Shandong 265100, China;Department of Nosocomial Infection Management ,the People＇s Hospital of Haiyang,Haiyang,Shandong 265100, China;Department of Nursing, the People ~s Hospital of Haiyang, Haiyang, Shandong 265100, Chin;Department of Chinese and English 146 Class, Queen Mary of Nanchang University, Nanchang, Jiangxi 330031, China)
出处
《中国基层医药》
CAS
2018年第11期1439-1443,共5页
Chinese Journal of Primary Medicine and Pharmacy
关键词
脑出血
奥拉西坦
依达拉奉
疏血通
Cerebral hemorrhage
Oxiracetam
Edaravone
Shuxuetong
