摘要
目的探讨3.0T磁共振弥散加权成像(DWI)和表面弥散系数(ADC)在前列腺癌诊断及鉴别诊断中的应用价值。方法回顾性分析65例经穿刺活检病理证实的前列腺疾病患者,其中前列腺癌组21例,前列腺炎组19例,良性前列腺增生(BPH)组25例,测量病变区及前列腺增生外周带的ADC值,并在癌与非癌组之间进行受试者操作特征曲线(ROC)分析。结果前列腺癌组ADC值为(0.74±0.10)×10^(-3)mm^2/s,前列腺炎组为(0.98±0.07)×10^(-3)mm^2/s,BPH组中央带为(1.21±0.09)×10^(-3)mm^2/s,外周带为(1.38±0.14)×10^(-3)mm^2/s,组间ADC值两两比较,差异均有统计学意义(P<0.01)。根据ROC曲线,当ADC值为0.95×10^(-3)mm^2/s时,诊断的敏感性达92.8%,特异性达100%,ROC曲线下面积为0.995。结论磁共振DWI和ADC值可用于前列腺癌的诊断和鉴别诊断,具有很高的临床应用价值。
Objective To explore the applicability of diffusion-weighted imaging（ DWI） and apparent diffusion coefficient（ ADC） values in the diagnosis and differential diagnosis of prostatic cancer at 3. 0 T MR. Methods A total 65 patients who had been confirmed by pathological results were enrolled in this retrospective study,including 21 cases of prostatic cancer,19 cases of prostatitis and 25 cases of benign prostatic hyperplasia（ BPH）. The ADC values of each lesion and peripheral zone of BPH were measured and analyzed with one-way ANOVA and ROC analysis. Results The mean ADC values of the cancerous area,inflammatory area,prostatic central gland and peripheral zone of BPH were（ 0. 74 ± 0. 10） × 10^-3） mm2/s,（ 0. 98 ± 0. 07） × 10^-3） mm2/s,（ 1. 21 ± 0. 09） × 10^-3） mm2/s and（ 1. 38 ± 0. 14） × 10^-3） mm2/s,respectively. There was statistically significant difference in ADC values between the intergroups（ P〈0. 01）. With the ROC cut point set at 0. 95 × 10^-3） mm2/s,the diagnostic sensitivity and specificity for prostate cancer were 92. 8% and 100% respectively,while the area under the ROC curve（ AUC） was 0. 995 ± 0. 005. Conclusions DWI and ADC values have good clinical applicability in the diagnosis and differential diagnosis of prostate cancer.
作者
常国庆
夏兆云
CHANG Guoqing;XIA Zhaoyun(Department of Radiology, Jiangsu Provincial Corps Hospital, Chinese People＇ s Armed Po- lice Force, Yangzhou 225003, Chin)
出处
《武警医学》
CAS
2018年第4期358-360,366,共4页
Medical Journal of the Chinese People's Armed Police Force
关键词
前列腺
前列腺癌
磁共振成像
弥散
prostate
prostatic cancer
magnetic resonance imaging
diffusion-weighted imaging
