摘要
目的:研究小于8岁性早熟女童阴道出血的病因。方法:对宁波市北仑区小港医院儿科2014年1月到2016年12月收治的68例小于8岁性早熟女童的临床资料进行回顾性分析,对所有患儿的病史进行详细询问,对其进行身高,体重,乳房,外阴等项目的体检,并对其骨龄片进行摄取,并对其进行B超检查,主要对其卵巢,子宫进行扫描,对其进行头颅MRI检查,LHRH激发试验,运用化学发光法检测其PRL,FSH,E2,T水平。结果:68例患儿中,54例为假性性早熟,其中24例为外源性性早熟,18例为卵巢囊肿,12例病因不明,分别占44.4%,33.3%,22.2%;14例为真性性早熟,分别占总数的79.4%,20.6%。假性性早熟患儿中外源性性早熟,卵巢囊肿患儿均有一定程度的色素沉着在乳晕及外阴,而和假性性早熟患儿相比,真性性早熟患儿具有显著较大的乳房发育,同时外阴阴唇阴蒂均已发育。结论:小于8岁性早熟女童阴道出血的病因主要为假性性早熟,而假性性早熟的病因主要为外源性性早熟,卵巢囊肿。临床应该依据病因及时给予患儿有针对性的治疗,从而将不良后果的发生几率降低到最低限度。
Objective： To study the etiology of vaginal bleeding in less than 8-year-oldgirls with precocious pu-berty. Methods： 68 girls who were less than8 years old with precocious puberty treated in Department of Pediatrics of Beilun District Xiaogang Hospital of Ningbo from January 2014 to December 2016 were analyzed retrospectively. Medical history of all patients were taken in detail and physical examination was conducted to understand the details of height,weight,breast,vulva and other items. The bone age was tested. The patients receivedultrasound examination to scan ovary and uterus. Brain MRI examination and the LHRH excitation test were done. The PRL,FSH,E2 and T levels were detected by chemiluminescence detection. Results： Amongthe 68 patients,there were 54 cases ofpseudo precocious puberty,including 24 cases of exogenous precocious puberty,18 cases of ovarian cyst,and 12 cases of unknown etiology,accounting for 44. 4%,33. 3% and 22. 2% respectively. There were 14 cases of true precocious puberty,accounting for 20. 6%.Certain degrees of pigmentation on the areola and vulva occurred in patients with exogenous sexual precocity and ovarian cyst. Compared with pseudo precocious puberty,true precocious puberty children had significant breast development,and developed clitoris labium of vulva. Conclusions： The main etiology of vaginal bleeding in less than 8-year-old girls with precocious puberty are pseudo precocious puberty,and the main etiology of pseudo precocious puberty are exogenous precocious puberty and ovarian cysts. Targeted treatment should be taken in a timely manner based on the etiology of the disease,thereby reducing the incidence of adverse consequences of children to a minimum.
作者
施霞静
魏若菡
金佩丽
SHI Xiajing;WEI Ruohan;JIN Peili(Department of Pediatrics ,Beilun District Xiaogang Hospital of Ningbo , Ningbo 315801, Zhejiang , China;Department of Obstetrics and Gynecology, Taizhou First People＇s Hospital, Taizhou 318020, Zhejiang, China;Department of Pediatrics ,Jiaxing Maternal and Child Health Care Hospital ,Jiaxing 314000, Zhejiang, China)
出处
《中国性科学》
2018年第4期67-69,共3页
Chinese Journal of Human Sexuality
基金
浙江省嘉兴市科技计划公益类项目(2016AY23063)
关键词
小于8岁性早熟女童
阴道出血
病因
临床研究
Less than 8-year-old girls with precocious puberty
Vaginal bleeding
Etiology
Clinical study
