摘要
在多种疾病的发生发展及器官移植的过程中,缺血再灌注损伤(I/R)是重要的病理生理学基础。氢气作为一种新的抗氧化剂,在多种器官缺血再灌注疾病和器官移植模型中的作用被广泛研究。这里,我们回顾与氢气治疗相关的缺血再灌注损伤性疾病及器官移植的研究进展,讨论氢气在器官缺血再灌注损伤中的保护效应和作用机制,并对未来研究进行展望。大量实验证据表明,氢气能够通过选择性抗氧化减少氧化应激,对抗炎症,减少凋亡,在不同的缺血再灌注疾病模型及器官移植中发挥显著的保护治疗作用。氢气对缺血再灌注损伤的作用研究为未来氢气医学临床应用奠定了基础,但相关机制和临床研究仍然需要进一步加强。
Ischemia-reperfusion （I/R） injury is a crucial pathophysiologic process in the development of various diseases or during organ transplantation. Hydrogen has been widely researched as a potential antioxidant in isehemia- reperfusion models of multiple diseases and organ transplantation. Herein, the authors review the current literature regarding the effects of hydrogen on isehemia-reperfusion injury and organ transplantation. Existing data on the effects and mechanisms of hydrogen on ischemia-reperfusion injury and organ transplantation are specifically reviewed and coupled with further suggestions for future work. In general, a substantial body of experimental evidence suggests that hydrogen significantly has a therapeutic effect on ischemia-reperfusion injury in models of multiple diseases and organ transplantation by inhibiting inflammatory response, oxidative stress and apoptosis through several underlying mechanisms. On this basis, further animal experiments and preliminary human clinical trials regarding the effects of hydrogen on ischemia-reperfusion injury are need to be conducted for the early use of hydrogen as a drug in the clinic.
作者
黄俊隆
刘文武
孙学军
HUANG Jun-long;LIU Wen-wu;SUN Xue-jun(Department of Navy Aeromedicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, China;Department of Diving and Hyperbaric Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, China)
出处
《解剖学报》
CAS
CSCD
北大核心
2018年第3期406-411,共6页
Acta Anatomica Sinica
基金
国家自然科学基金(81772015
81371316)
关键词
氢气
缺血再灌注损伤
器官移植
Hydrogen
Ischemia/reperfusion injury
Organ transplantation
