摘要
目的研究子宫肌瘤患者外周血中胰岛素样生长因子(IGF)-Ⅰ、IGF-Ⅱ水平的变化,及其与雌激素受体(ER)的相关性。方法选取子宫肌瘤患者共100例(实验组),同时选取健康人群100例作为对照组,采用酶联免疫吸附法检测实验组和对照组外周血胰岛素样生长因子-Ⅰ、胰岛素样生长因子-Ⅱ的表达水平,采用免疫组织化学染色的方法测定子宫肌瘤组织中雌激素受体(ER)的表达情况。结果实验组患者外周血IGF-Ⅰ表达水平为(1301.19±101.02)μg/L、IGF-Ⅱ表达水平为(801.89±21.45)μg/L,对照组外周血IGF-Ⅰ表达水平为(789.01±31.00)μg/L、IGF-Ⅱ表达水平为(212.01±35.06)μg/L,实验组的表达水平高于对照组,差异具有统计学意义(P<0.05);子宫肌瘤ER阳性患者外周中IGF-Ⅰ和IGF-Ⅱ水平高于子宫肌瘤ER阴性患者,分别为(1463.71±79.81)μg/L、(1097.62±69.01)μg/L;(871.89±23.12)μg/L、(515.71±21.01)μg/L。结论子宫肌瘤患者外周血中IGF-Ⅰ和IGF-Ⅱ水平与子宫肌瘤ER呈正相关,二者有密切的联系。
Objective To investigate the changes of peripheral blood insulin-like growth factor（ IGF）-Ⅰ and IGF-Ⅱ in patients with uterine myoma and their relationship with estrogen receptor（ ER）. Methods 100 cases of uterine leiomyoma were selected as the experimental group. 100 healthy people were selected as the control group. The levels of IGF-Ⅰ and IGF-Ⅱ in peripheral blood of the experimental group and the control group were detected by enzyme-linked immunosorbent assay,the expression of ER in uterine fibroid tissue was determined by immunohistochemical staining. Results The expression of IGF-Ⅰ in the peripheral blood was（ 1301. 19 ± 101. 02） μg/L,and IGF-Ⅰ was（ 801. 89 ± 21. 45） μg/L in the experimental group; and IGF-Ⅰ was（ 789. 01 ± 31. 00） μg/L,IGF-Ⅱ was（ 212. 01 ± 35. 06） μg/L in the control group,the expression level of the experimental group was higher than that of the control group（ P 〈 0. 05）. IGF-Ⅰ and IGF-Ⅱ levels of ER positive patients in peripheral blood of uterine leiomyoma were（ 1463. 71 ± 79. 81） μg/L,（ 1097. 62 ± 69. 01） μg/L,which were higher than those of ER negative patients,（ 871. 89 ± 23. 12） μg/L,（ 515. 71 ± 21. 01） μg/L. Conclusion The levels of IGF-Ⅰ and IGF-Ⅱ in peripheral blood of patients with uterine fibroids are positively correlated with the ER of uterine fibroids,they are closely related.
作者
宋瑜
SONG Yu(The 5th Hospital Affiliated to Zhengzhou University,Zhengzhou ,45005)
出处
《实用癌症杂志》
2018年第6期892-894,共3页
The Practical Journal of Cancer
