摘要
目的分析并探讨胃癌术后随访患者癌胚抗原(CEA)和糖链多肽抗原(CA19-9)的临床意义,从而为胃癌术后预后提供诊断价值。方法选取胃癌患者201例。根据术后3年随访是否复发或转移为依据分为观察组(n=110)与对照组(n=91)。定期检测患者血清CEA水平和CA19-9水平,分析CEA、CA19-9阳性与复发及转移的关系。结果治疗前,观察组患者血清CEA和CA19-9水平明显高于对照组。经统计学检验,差异有统计学意义(P<0.05)。治疗后,观察组患者血清CEA和CA19-9水平明显高于对照组。经统计学检验,差异有统计学意义(P<0.05)。CEA敏感性为70.91%,特异性为89.01%。CA19-9敏感性为69.09%,特异性为91.21%。联合检测敏感性为82.72%,特异性为93.41%。观察组患者CEA阳性至确诊时间为(2.42±0.62)个月,CA19-9阳性至确诊时间为(2.47±0.64)个月,双阳性至确诊时间为(1.84±0.42)个月。结论胃癌患者术后随访定期检测血清CEA和CA19-9水平有利于评估预后效果,且对早期诊断复发及转移有重要参考价值。
Objective To analyze and discuss the clinical significance of CEA and CA19-9 in patients with gastric cancer after operation,so as to provide the diagnostic value for postoperative prognosis of gastric cancer. Methods 201 cases of gastric cancer were selected. And divided into the observation group（ n = 110） and the control group（ n = 91） according to whether recurrence or metastasis occurred after 3 years. Serum levels of CEA and CA19-9 were measured regularly,and the relationship between CEA,CA19-9 positive and recurrence and metastasis was analyzed. Results Before treatment,the levels of serum CEA and CA19-9 in the observation group were significantly higher than those of the control group. the difference was statistically significant（ P 〈 0. 05）. After treatment,the levels of serum CEA and CA19-9 in the observation group were significantly higher than those of the control group. the difference was statistically significant（ P 〈 0. 05）. CEA sensitivity was 70. 91% and specificity was89. 01%. The sensitivity and specificity of CA19-9 were 69. 09% and 91. 21% respectively. The combined detection sensitivity was 82. 72% and the specificity was 93. 41%. In the observation group,the positive CEA time was（ 2. 42 ± 0. 62） months,the positive CA19-9 time was（ 2. 47 ± 0. 64） months and the double positive time was（ 1. 84 ± 0. 42） months. Conclusion The regular follow-up of gastric cancer patients with serum CEA and CA19-9 levels is conducive to the assessment of prognosis,and the early diagnosis of recurrence and metastasis have important reference value.
作者
黑涛
HEI Tao(The Seventh People＇s Hospital of Zhengzhou,Zhengzhou,450016)
出处
《实用癌症杂志》
2018年第6期965-967,共3页
The Practical Journal of Cancer
关键词
胃癌
癌胚抗原
糖链多肽抗原
预后
复发
Gastric cancer
Carcinoembryonic antigen
CA19-9
Prognosis
Relapse
