摘要
目的探讨血清糖类抗原125(CA125)、癌胚抗原(CEA)及肽结合羟脯氨酸(TAM)联合检测在妇科肿瘤的临床诊断中的应用价值。方法选取妇科肿瘤患者200例,以病理学诊断为对照,依据良恶性分为恶性组(n=50)和良性组(n=150)。采用电化学发光法检测血清CA125、CEA水平,采用化学比色法检测血清TAM水平,采用ROC曲线分析上述因子鉴别良恶性肿瘤的诊断效能,统计分析所有患者血清CA125、CEA、TAM水平。结果恶性组患者血清CA125、CEA及TAM水平明显高于良性组,差异有统计学意义(P<0.05)。ROC曲线分析结果显示,在鉴别良恶性肿瘤的敏感度、特异度、准确度方面,CA125以35 U/ml为临界值时,分别为81.00%、81.33%、82.00%;CEA以5.2 ng/ml为临界值时,分别为82.00%、83.33%、83.00%;TAM以95 U/ml为临界值时,分别为76.00%、80.00%、78.00%;三者联合检测时,分别为98.00%、94.00%、95.00%。三者联合检测的诊断价值明显高于三者单独检测,差异有统计学意义(P<0.05)。结论血清CA125、CEA及TAM水平与妇科肿瘤恶性病变有关,三者联合检测可有效提高鉴别妇科肿瘤良恶性病变的诊断效能,值得临床进一步推广。
Objective To discuss the application value of serum carbohydrate antigen 125（ CA125）,carcinoembryonic antigen（ CEA） and tumor related substances（ TAM） detection in the clinical diagnosis of gynecological tumors. Methods 200 patients with gynecological tumors were selected. In pathological diagnosis for comparison,according to the benign and malignant,all patients were divided into malignant group（ n = 50） and benign group（ n = 150）,electrochemical luminescence method was used to detect the serum CA125,CEA levels,chemical colorimetry was used to detect serum level of TAM,ROC curve analysis was used to identify the above factor in the diagnostic performance of benign and malignant tumor,statistical analyzed all patients of serum CA125,CEA,TAM. Results The levels of serum CA125,CEA and TAM of malignant group patients were significantly higher than those of benign group,the difference was statistically significant（ P 〈 0. 05）; ROC curve analysis showed that,in differentiating benign and malignant tumors of sensitivity,accuracy,specific degree,CA125 in 35 u/ml of the critical value,were respectively 81. 00%,81. 33% and 81. 00%,the CEA to the critical value for 5. 2 ng/ml,were respectively 82. 00%,83. 33% and83. 00%,TAM to 95 u/ml of the critical value,were respectively 76. 00%,80. 00% and 76. 00%,the combined detection were98. 00%,94. 00% and 95. 00% respectively,combined detection were significantly higher than the 3 factors alone,the difference was statistically significant（ P 〈 0. 05）. Conclusion Serum levels of CA125,CEA and TAM are associated with gynecological malignant tumor,combined detection can effectively increase the efficiency of the diagnosis of benign and malignant lesions of gynecological tumors,it’s worthy of further clinical promotion.
作者
翟春霞
ZHAI Chunxia(The People＇s Hospital of Hebi,Hebi,45800)
出处
《实用癌症杂志》
2018年第6期1028-1030,共3页
The Practical Journal of Cancer
关键词
糖类抗原125
癌胚抗原
肽结合羟脯氨酸
妇科肿瘤
诊断
Carbohydrate antigen 125
Carcinoembryonic antigen
Tumor related substances
Gynecological tumors
Diagnosis
