摘要
目的探讨实时组织弹性成像定量分析技术(real-time tissue elastography,RTE)检测病毒性乙型肝炎肝纤维化分期的价值。方法利用实时组织弹性成像定量分析182例慢性乙型肝炎患者(病例组)及60例健康志愿者(对照组)肝脏弹性的11个变量,以肝组织取活检的病理肝纤维化分级为依据分组,通过多元回归方程,得出肝纤维化指数(LF Index)计算公式。比较LF Index与肝纤维化分级的相关性。结果LF Index=0.043AREA%+4.520SKEW+0.033MEAN-1.002KURT。对照组与病例组之间LF Index的差异均有统计学意义(P<0.05)。LF Index相隔期别的比较,S0与S2、S0与S3、S0与S4之间差异有统计学意义,S1与S3、S1与S4之间差异有统计学意义,S2与S4之间差异有统计学意义(P均<0.05)。肝纤维化分期相邻期别的比较,除S1与S2之间差异有统计学意义(P<0.05),其他相邻期别差异无统计学意义。结论 RTE定量分析可以成为判断乙型肝炎肝纤维化分期的一种无创性检查方法。
Objective To investigate the value of real-time tissue elastography （RYE） in detection of hepatic fibrosis stage in paitents with hepatitis B. Methods Eleven variables of liver inflammation were analyzed by RTE in 182 patients with chronic hepatitis B and 60 healthy volunteers. Group was based on histopathological liver fibrosis grading liver biopsy, and the formula for calculating the elasticity of liver fibrosis（LF Index） was obtained by multiple regression equation. The LF Index = 0.043AREA% ＋ 4.520SKEW ＋ 0.033MEAN - 1.002KURT. Correlation between LF Index and liver fibrosis grade was compared. Results The difference of LF Index between the control group and the case group was significant （P 〈 0.05）. Comparison result of LF Index in non-adjacent stage was that there were significant differences between SO and S2, SO and S3, SO and S4 and there was significant difference between S1 and S3, S1 and S4, S2 and S4 （P 〈 0.05）. Comparison result of liver fibrosis in non-adjacent stage was that there was significant difference between SI and S2 （P 〈 0.05）, and no significant difference was found in other adjacent stages. Conclusion RTE quantitative analysis can be a noninvasive method for judging the stage of hepatic fibrosis in patients with hepatitis B.
作者
郑颖
孟繁坤
徐晓鸾
穆晓洁
Zheng Ying;Meng Fankun;Xu Xiaoluan;Mu Xiaojie(Ultrasound and Functional Diagnostic Center, Beijing You＇ an Hospital, Capital Medical University, Beijing 100069, China)
出处
《北京医学》
CAS
2018年第4期338-341,I0003,共5页
Beijing Medical Journal
