摘要
目的检测结肠腺癌中真核翻译起始因子3h(eukaryotic translation initiation factor 3 h,EIF3h)、基质金属蛋白酶-10(matrix metallopeptidase 10,MMP-10)和MMP-11的表达,分析其相关性.方法选择110例经病理医师确诊的结肠腺癌作为观察组,选择43例结肠黏膜高级别上皮内瘤变组织作为对照组1,选择43例结肠黏膜低级别上皮内瘤变组织作为对照组2,选择43例非肿瘤性结肠黏膜组织作为对照组3.应用免疫组化法检测四组中EIF3h和MMP-10、MMP-11蛋白的表达.结果四组中EIF3h、MMP-10和MMP-11的表达差别有统计学意义,观察组中三种蛋白的表达与淋巴结转移相关,EIF3H的表达与肿瘤最大径、分化程度、增殖指数及TNM分期相关,MMP-10、MMP-11与脉管累犯相关.三者均与性别、年龄和炎细胞浸润程度无关.观察组中MMP-10和MMP-11呈正相关.结论结肠腺癌中三者高表达是促进肿瘤形成和进展的重要因素之一,MMP-10和MMP-11之间可能具有协同正向作用.EIF3h可能与预后有关.
To detect the expression of eukaryotic translation initiation factor 3h （EIF3h）, matrix metallopeptidase 10（MMP-10）, and matrix metallopeptidase 11 （MMP-11） in colonic adenocarcinoma and to analyze their clinical significance. METHODS One hundred and ten colonic adenocarcinoma tissues, 43 high-grade colorectal intTaepithelial neoplasia tissues, 43 low-grade colorectal intraepithelial neoplasia tissues, and 43 normal colonic mucosal tissues were collected. The expression of EIF3h, MMP-10, and MMP-11 in the above tissues was detected by immunohistochemistry. RESLIL TS The expression of EIF3h, MMP-10, and MMP-11 differed significantly among the four groups. Expression of EIF3h, MMP-10, and MMP-11 was correlated with lymph node metastasis. Expression of EIF3h was correlated with tumor size, differentiation, proliferation index, and TNM stage. Expression of MMP-10 and MMP-11 was correlated with vascular invasion. There was a positive correlation between MMP-10 and MMP-11 expression in colonic adenocarcinoma. CONCLUSION High expression and synergy of EIF3h, MMP-10, and MMP-11 can promote tumor formation and progression in colonic adenocarcinoma. EIF3h may be associated with the prognosis of colonic adenocarcinoma.
作者
沈渊
沈瑛
刘江
施杰民
丁建
Yuan Shen;Ying Shen;Jiang Liu;Jie-Min Shi;Jian DingY(Department of Internal Medicine, Huzhou Sixth Hospital, Huzhou 313000, Zhejiang Province, China;Depamnent of Gastroenterology, Huzhou Central Hospital, Huzhou 313000, Zhejiang Province, Chin)
出处
《世界华人消化杂志》
CAS
2018年第14期834-841,共8页
World Chinese Journal of Digestology
关键词
结肠腺癌
EW3H
MMP-10
MMP-11
Colonic adenocarcinoma
Eukaryotic translationinitiation factor 3 h
Matrix metallopeptidase 10
Matrixmetallopeptidase 11
