摘要
目的探讨晚期氧化蛋白产物(AOPP)对冠心病合并糖尿病患者冠状动脉支架植入术(PCI)后支架内再狭窄(ISR)的预测价值。方法采用前瞻性队列研究方法纳入冠心病合并糖尿病、行冠状动脉造影(CAG)及PCI患者682例,根据AOPP平均水平分为低AOPP组(AOPP≤50.51μmol/L,n=350)和高AOPP组(AOPP>50.51μmol/L,n=332),观察PCI后1年两组ISR发生率。结果高AOPP组PCI后ISR高于低AOPP组(10.24%vs 5.14%,P<0.05)。Logistic回归分析显示,AOPP>50.51μmol/L是PCI后ISR的独立危险因素(OR1.842,95%CI 1.568~1.999,P<0.05)。结论AOPP可能是预测冠心病合并糖尿病患者PCI后ISR的生物标记物之一。
Objective To investigatethe value of advanced oxidation protein products（AOPP）in predicting in-stent restenosis in patients with coronary heart disease and diabetes mellitus undergoing percutaneous coronary intervention（PCI）. Methods A total of 682 patients with coronary heart disease and diabetes mellitus undergoing coronary angiography（CAG）and PCI were enrolled in this prospective cohort study.All the subjects were divided into two groups：low level of AOPP group（AOPP≤50.51μmol/L,n=350）and high level of AOPP group（AOPP〉50.51μmol/L,n=332）according to the average level of AOPP.Therate of In-stent restenosis（ISR）was evaluated after1-year follow-up. Results The rate of ISR was higher in high level AOPP group than in low level AOPP group（10.24%vs 5.14%,P〈0.05）.Logistic regression analysis showed that AOPP〉50.51μmol/L was an independent risk factor for ISR prediction（OR1.842,95%CI 1.568-1.999,P〈0.05）. Conclusion AOPP may be a biomarker for predicting ISR in patients with coronary heart disease and diabetes mellitus undergoing PCI.
作者
李强
李新阳
冯文化
LI Qiang;LI Xinyang;FENG Wenhua(Department of Special Wards, Nan Yang City Center Hospital, Nanyang 473000, Chin)
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2018年第5期394-397,共4页
Chinese Journal of Diabetes
关键词
晚期氧化蛋白产物
冠心病
糖尿病
支架内再狭窄
生物标记物
Advanced oxidation protein products
Coronary heart disease
Diabetes mellitus
In-stentrestenosis
Biomarker
