摘要
吲哚类化合物作为医药、农药、染料以及其他精细化工产品的中间体,其应用越来越广。5-氰基-6-硝基吲哚的合成方法目前无文献报道,以5-溴吲哚为原料,经还原、硝化、保护、取代、脱保护和氧化6步反应首次合成目标产物,其结构经^1HNMR、^13CNMR和MS确证。该路线具有原料廉价易得、操作简单、后处理方便且收率较高等优点,适合工业化生产。
Indole derivatives apply more and more extensively severing as pharmaceuticals,pesticides,dyes and other fine chemical products intermediates.The synthesis of 5-cyano-6-nitroindole hasn＇t been reported in the literature up to now. This work initially synthesize it based on 5-bromoindole by means of six steps of reduction,nitration,protection,substitution,deprotection and oxidation.The structure was confirmed by ^1HNMR,^13CNMR and MS.The route can well meet with the needs of industrial production given cheap raw materials,simple operation,easy post-processing and high yield.
作者
赵庆平
邹国军
周志旭
黄筑艳
ZHAO Qing-ping;ZOU Guo-jun;ZHOU Zhi-xu;HUANG Zhu-yan(School of Pharmaceutical Sciences, Guizhou University, Guiyang 550025, China;Guizhou Engineering Laboratory for Synthetic Drugs, Guiyang 550003, China;Key Laboratory of Guizhou for Fermentation Engineering and Biomedicine, Guiyang 550003, China)
出处
《化学试剂》
CAS
北大核心
2018年第6期601-604,共4页
Chemical Reagents
基金
贵州省科技计划项目(黔科合LH字[2016]7442号)
贵州省科技计划项目(黔科合[2017]1049)
