摘要
目的探讨噻托溴铵对尘肺并慢性阻塞性肺疾病患者肺功能和血气分析指标的影响。方法选取宜昌市秭归县中医医院2015年9月—2016年9月收治的尘肺并慢性阻塞性肺疾病患者63例,根据不同的治疗方法将患者分为对照组(n=30)与观察组(n=33)。对照组患者采用常规治疗,观察组患者在对照组基础上给予噻托溴铵治疗。比较两组患者治疗前后肺功能指标[肺活量(VC)、每分钟气量(VE)、最大通气量(MVV)、潮气量(VT)]及血气分析指标[动脉血液酸碱度(pH)值、血氧饱和度(SaO_2)、动脉血氧分压(PaO_2)、动脉血二氧化碳分压(PaCO_2)]。结果治疗前,两组患者VC、VE、MVV、VT比较,差异无统计学意义(P>0.05);治疗后,观察组患者VC、VE、MVV、VT高于对照组(P<0.05)。治疗前,两组患者pH值、SaO_2、PaO_2、PaCO_2比较,差异无统计学意义(P>0.05);治疗后,观察组患者pH值、PaO_2及SaO_2高于对照组,PaCO_2低于对照组(P<0.05)。观察组不良反应发生率低于对照组(P<0.05)。结论噻托溴铵可有效改善尘肺并慢性阻塞性肺疾病患者的肺功能及血气分析指标,且安全性较高。
Objective To investigate the impact of tiotropium bromide on lung function and blood gas index of pneumoconiosis complicated with chronic obstructive pulmonary disease patients.Methods A total of 63 cases of pneumoconiosis complicated with chronic obstructive pulmonary disease patients were selected from September 2015 to September 2016 in Yichang Zigui County Hospital of Traditional Chinese Medicine,which were divided into control group（n=30） and observation group（n=33） according to different treatment.The control group was given routine treatment,the observation group was treated with tiotropium bromide based on control group.The lung function（VC,VE,MVV,VT） and blood gas index（pH,SaO2,PaO2,PaCO2） before and after treatment were compared between the two groups,and the incidence of adverse reactions were observed.Results Before treatment,no significant differences of VC,VE,MVV or VT was found between the two groups（P〉0.05）;after treatment,the VC,VE,MVV,VT in observation group were higher than control group（P〈0.05）.Before treatment,no significant differences of pH,SaO2,PaO2 or PaCO2 was found between the two groups（P〉0.05）;after treatment,the observation group of pH、SaO2,PaO2 were higher than control group,PaCO2 was lower than control group（P〈0.05）.The incidence rate of adverse reactions in observation group was lower than control group（P〈0.05）.Conclusion Tiotropium bromide could effectively improve the lung function and blood gas index of pneumoconiosis complicated with chronic obstructive pulmonary disease patients,and with high safety.
作者
韩海峰
HAN Hai-feng(Department of Emergency, Yichang Zigui County Hospital of Traditional Chinese Medicine, Zigui 443600, Chin)
出处
《临床合理用药杂志》
2018年第15期3-4,6,共3页
Chinese Journal of Clinical Rational Drug Use
关键词
尘肺
肺疾病
慢性阻塞性
噻托溴铵
肺功能
血气指标
Pneumoconiosis
Pulmonary disease
chronic obstructive
Tiotropium bromide
Lung function
Blood gas index
