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慢性心力衰竭患者血清Lp-PLA2、CgA水平与心室重构的关系 被引量:28

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摘要 目的探讨脂蛋白相关磷脂酶A2(Lp-PLA2)、嗜铬粒蛋白(CgA)与慢性心力衰竭患者心室重构的关系。方法选择慢性心力衰竭患者97例(心衰组),按照美国纽约心脏病协会(NYHA)心功能分级,NYHAⅡ级35例,NYHAⅢ级29例,NYHAⅣ级33例。同期体检健康者40例作为对照组。心衰组于入院次日,对照组于体检日采集清晨空腹肘静脉血,采用ELISA法检测血清Lp-PLA2、CgA水平;同日,采用超声心动图检测左心房内径(LAD)、右心室内径(RVD)、左心室舒张末内径(LVEDD)、左心室射血分数(LVEF),并计算左心室质量指数(LVMI)。结果心衰组血清Lp-PLA2、CgA水平均高于对照组(P均<0.05);心衰组随着心功能分级增加,血清Lp-PLA2、CgA水平逐渐升高(P均<0.05)。心衰组LAD、RVD、LVEDD、LVMI均高于对照组,LVEF低于对照组(P均<0.05);心衰组随着心功能分级增加,LAD、RVD、LVEDD、LVMI、LVEF变化越明显(P均<0.05)。慢性心力衰竭患者血清Lp-PLA2、CgA与LAD、RVD、LVEDD、LVMI均呈正相关关系,与LVEF均呈负相关关系(P均<0.05)。结论血清Lp-PLA2、CgA水平升高与慢性心力衰竭患者心室重构有关。血清Lp-PLA2、CgA水平可作为临床辅助诊断慢性心力衰竭及评估患者病情程度的指标。
出处 《山东医药》 CAS 2018年第20期88-90,共3页 Shandong Medical Journal
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